ReviewAntioxidants & redox signaling2014
Skin, reactive oxygen species, and circadian clocks.
Review in Antioxidants & redox signaling, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed.
- Temporally Optimized Antioxidant Serums for Daytime Defense and Nighttime Repair: A Multicenter Clinical Investigation.Dermatology and therapy · 2026Article
- Vitamin D as a Regulator of the Biological Clock-Implications for Circadian-Metabolic Dysregulation.International journal of molecular sciences · 2026Review
- Therapeutic potential of ginsenosides in circadian rhythm-based skin disorders.Journal of ginseng research · 2025Review
- Role of Nutritional Elements in Skin Homeostasis: A Review.Biomolecules · 2025Review
- Regulation of dermal circadian pathways by a novel topical formulation.International journal of cosmetic science · 2025Article
- Advances in the application of multi-omics analysis in skin aging.Frontiers in aging · 2025Review
- Research progress on the role of fascia in skin wound healing.Burns & trauma · 2025Review
- Evaluating the Effects of Laser Treatments on Visible Changes in the Photoaging Process of the Skin Using Specialized Measuring Devices.Journal of clinical medicine · 2024Article
- The Promising Role of Polyphenols in Skin Disorders.Molecules (Basel, Switzerland) · 2024Review
- Insights on the role of L-lactate as a signaling molecule in skin aging.Biogerontology · 2023Review
- Circadian Oscillations in Skin and Their Interconnection with the Cycle of Life.International journal of molecular sciences · 2023Review
- Exploring the potential of cold plasma therapy in treating bacterial infections in veterinary medicine: opportunities and challenges.Frontiers in veterinary science · 2023Review
- Circadian Control of Mitochondria in Reactive Oxygen Species Homeostasis.Antioxidants & redox signaling · 2022Review
- Logic of the Temporal Compartmentalization of the Hepatic Metabolic Cycle.Physiology (Bethesda, Md.) · 2022Review
- Magnetic field effects in biology from the perspective of the radical pair mechanism.Journal of the Royal Society, Interface · 2022Review
- Ischemia-Modified Albumin-A Potential New Marker of Oxidative Stress in Dermatological Diseases.Medicina (Kaunas, Lithuania) · 2022Review
- Cosmeceutical Therapy: Engaging the Repercussions of UVR Photoaging on the Skin's Circadian Rhythm.International journal of molecular sciences · 2022Review
- Protective Role of Melatonin and Its Metabolites in Skin Aging.International journal of molecular sciences · 2022Review
- Plant-Derived Antioxidants: Significance in Skin Health and the Ageing Process.International journal of molecular sciences · 2022Review
- Bioactive Compounds for Skin Health: A Review.Nutrients · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
significanceSkin, a complex organ and the body's first line of defense against environmental insults, plays a critical role in maintaining homeostasis in an organism. This balance is maintained through a complex network of cellular machinery and signaling events, including those regulating oxidative stress and circadian rhythms. These regulatory mechanisms have developed integral systems to protect skin cells and to signal to the rest of the body in the event of internal and environmental stresses. RECENT ADVANCES: Interestingly, several signaling pathways and many bioactive molecules have been found to be involved and even important in the regulation of oxidative stress and circadian rhythms, especially in the skin. It is becoming increasingly evident that these two regulatory systems may, in fact, be interconnected in the regulation of homeostasis. Important examples of molecules that connect the two systems include serotonin, melatonin, vitamin D, and vitamin A. CRITICAL ISSUES: Excessive reactive oxygen species and/or dysregulation of antioxidant system and circadian rhythms can cause critical errors in maintaining proper barrier function and skin health, as well as overall homeostasis. Unfortunately, the modern lifestyle seems to contribute to increasing alterations in redox balance and circadian rhythms, thereby posing a critical problem for normal functioning of the living system. FUTURE DIRECTIONS: Since the oxidative stress and circadian rhythm systems seem to have areas of overlap, future research needs to be focused on defining the interactions between these two important systems. This may be especially important in the skin where both systems play critical roles in protecting the whole body.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.