ArticleHistopathology2013
Pancreatic intraepithelial neoplasia and histological changes in non-neoplastic pancreas associated with neoadjuvant therapy in patients with pancreatic ductal adenocarcinoma.
Article in Histopathology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Defining post-operative pancreatitis as a new pancreatic specific complication following pancreatic resection.HPB : the official journal of the International Hepato Pancreato Biliary Association · 2016Pooled it
- Upfront surgery vs. neoadjuvant therapy in pancreatic cancer with venous involvement: a multicenter retrospective analysis.Langenbeck's archives of surgery · 2026Observational
- Pancreatic extracellular volume fraction on multiphasic contrast-enhanced computed tomography for predicting pancreatic fistula after pancreatoduodenectomy.Surgery today · 2026Article
- Article
- Letter to the editor: the nonnegligible effect of neoadjuvant therapy for patients with borderline resectable pancreatic ductal adenocarcinoma.Gland surgery · 2021Article
- Borderline resectable pancreatic cancer: Certainties and controversies.World journal of gastrointestinal surgery · 2021Review
- Spatial and phenotypic characterization of pancreatic cancer-associated fibroblasts after neoadjuvant treatment.Histology and histopathology · 2020Article
- Early Detection in a Mouse Model of Pancreatic Cancer by Imaging DNA Damage Response Signaling.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2020Article
- Usefulness ofCancer medicine · 2020Article
- Tumor-insular Complex in Neoadjuvant Treated Pancreatic Ductal Adenocarcinoma Is Associated With Higher Residual Tumor.The American journal of surgical pathology · 2020Article
- Association Between Pancreatic Fistula and Long-term Survival in the Era of Neoadjuvant Chemotherapy.JAMA surgery · 2019Article
- Residual Tumor Index: A Prognostically Significant Pathologic Parameter in Neoadjuvant-treated Pancreatic Ductal Adenocarcinoma.The American journal of surgical pathology · 2018Article
- Association Between Changes in Body Composition and Neoadjuvant Treatment for Pancreatic Cancer.JAMA surgery · 2018Article
- Novel nano-drug combination therapeutic regimen demonstrates significant efficacy in the transgenic mouse model of pancreatic ductal adenocarcinoma.American journal of cancer research · 2018Article
- Pathologic assessment of gastrointestinal tract and pancreatic carcinoma after neoadjuvant therapy.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2018Review
- Prognostic Significance of New AJCC Tumor Stage in Patients With Pancreatic Ductal Adenocarcinoma Treated With Neoadjuvant Therapy.The American journal of surgical pathology · 2017Article
- The inflammatory milieu within the pancreatic cancer microenvironment correlates with clinicopathologic parameters, chemoresistance and survival.BMC cancer · 2015Article
- Neoadjuvant therapy for pancreas cancer: past lessons and future therapies.World journal of gastroenterology · 2014Review
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
aimsTo study the histological changes in non-neoplastic pancreas and the effects on pancreatic intraepithelial neoplasia (PanIN) after neoadjuvant chemoradiation therapy (NCRT) for pancreatic ductal adenocarcinoma (PDAC). METHODS AND
resultsWe reviewed the archival H&E slides from 218 patients with PDAC who completed NCRT and pancreaticoduodenectomy. Sixty-five patients who underwent pancreaticoduodenectomy for PDAC without NCRT were used as controls. Various histological features were reviewed and correlated with NCRT and survival. The NCRT group had lower densities of PanIN2 (P = 0.004) and PanIN3 (P = 0.02) than the control group. The extent of fibrosis, the frequency of neuroma-like nerve proliferation and the frequency of islet cell aggregation were significantly higher in the NCRT group than in the control group (P < 0.05). The intensity of inflammation was less in the NCRT group than in the control group (P = 0.02). In the NCRT group, patents with moderate to severe fibrosis or grade 2 inflammation had poorer survival than those with mild fibrosis (P = 0.04) or those with grade 0 or grade 1 inflammation (P = 0.003), respectively.
conclusionsNon-neoplastic pancreatic tissue from patients who received NCRT had a reduced density of high-grade PanIN lesions, more pancreatic fibrosis, and higher frequencies of neuroma-like nerve proliferation and islet cell aggregation, but less inflammation, compared to tissue from those who did not receive NCRT.
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