ArticleAnnual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference2013
A simplified biophysical cell model for gastric slow wave entrainment simulation.
Article in Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 20 citations in OpenAlex.
- Neural regulation of slow waves and phasic contractions in the distal stomach: a mathematical model.Journal of neural engineering · 2024Article
- Steady-state approximations for Hodgkin-Huxley cell models: Reduction of order for uterine smooth muscle cell model.PLoS computational biology · 2023Article
- Computational models of autonomic regulation in gastric motility: Progress, challenges, and future directions.Frontiers in neuroscience · 2023Review
- Current applications of mathematical models of the interstitial cells of Cajal in the gastrointestinal tract.WIREs mechanisms of disease · 2021Review
- A theoretical study of the initiation, maintenance and termination of gastric slow wave re-entry.Mathematical medicine and biology : a journal of the IMA · 2015Article
- The impact of surgical excisions on human gastric slow wave conduction, defined by high-resolution electrical mapping and in silico modeling.Neurogastroenterology and motility · 2015Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Gastric electrical activity, also termed slow wave activity, is generated by a class of pacemaker cells called the interstitial cells of Cajal (ICC), which are organized with decreasing intrinsic frequencies along the stomach. In the healthy stomach, slow waves of different intrinsic frequencies converge to a single frequency with a constant phase-lag, in a process called entrainment. The main aim of this study was to develop a simplified biophysical ICC model that is capable of modeling the self-excitatory behavior and standard morphology of gastric slow waves. Entrainment of gastric slow waves was simulated in a one-dimensional (1D) model, with a linear gradient of intrinsic slow wave frequencies. In a coupled 1D model, the simulated slow waves were entrained to a single frequency; whereas in an uncoupled 1D model, the simulated slow waves occurred at different frequencies, resulting in loss of entrainment. The new cell model presents an option for future large multi-scale simulations of gastric slow waves in intact ICC network and diseased conditions where the loss of entrainment may lead to slow wave dysrhythmias and diminished gastric motility.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.