ArticleMolecular biology and evolution2014
Ancient origins of vertebrate-specific innate antiviral immunity.
Article in Molecular biology and evolution, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed.
- An ancient anthozoan protein reveals an alternative evolutionary path of antiviral signalling.Nature ecology & evolution · 2026Article
- Exploring the Innate Immunity in Invertebrates.Advances in experimental medicine and biology · 2025Review
- Similarities in the induction of the intracellular pathogen response in Caenorhabditis elegans and the type I interferon response in mammals.BioEssays : news and reviews in molecular, cellular and developmental biology · 2023Article
- TheProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Innate Immunity Mechanisms in Marine Multicellular Organisms.Marine drugs · 2022Review
- Divergences of theInternational journal of molecular sciences · 2022Article
- TIAMMAt: Leveraging Biodiversity to Revise Protein Domain Models, Evidence from Innate Immunity.Molecular biology and evolution · 2021Article
- Functional Characterization of the Cnidarian Antiviral Immune Response Reveals Ancestral Complexity.Molecular biology and evolution · 2021Article
- Article
- Analysis of chicken macrophage functions and gene expressions following infectious bronchitis virus M41 infection.Veterinary research · 2021Article
- Alignment-Integrated Reconstruction of Ancestral Sequences Improves Accuracy.Genome biology and evolution · 2020Article
- RIG-I regulates myeloid differentiation by promoting TRIM25-mediated ISGylation.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Do cells use passwords in cell-state transitions? Is cell signaling sometimes encrypted?Theory in biosciences = Theorie in den Biowissenschaften · 2020Article
- Polarized Trout Epithelial Cells Regulate Transepithelial Electrical Resistance, Gene Expression, and the Phosphoproteome in Response to Viral Infection.Frontiers in immunology · 2020Article
- The Innate Antiviral Response in Animals: An Evolutionary Perspective from Flagellates to Humans.Viruses · 2019Review
- DDX23, an Evolutionary Conserved dsRNA Sensor, Participates in Innate Antiviral Responses by Pairing With TRIF or MAVS.Frontiers in immunology · 2019Article
- Discovery of All Three Types in Cartilaginous Fishes Enables Phylogenetic Resolution of the Origins and Evolution of Interferons.Frontiers in immunology · 2019Article
- Dicer's Helicase Domain: A Meeting Place for Regulatory Proteins.Cold Spring Harbor symposia on quantitative biology · 2019Article
- Phylotranscriptomics suggests the jawed vertebrate ancestor could generate diverse helper and regulatory T cell subsets.BMC evolutionary biology · 2018Article
- Metagenomic sequencing suggests a diversity of RNA interference-like responses to viruses across multicellular eukaryotes.PLoS genetics · 2018Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Animals deploy various molecular sensors to detect pathogen infections. RIG-like receptor (RLR) proteins identify viral RNAs and initiate innate immune responses. The three human RLRs recognize different types of RNA molecules and protect against different viral pathogens. The RLR protein family is widely thought to have originated shortly before the emergence of vertebrates and rapidly diversified through a complex process of domain grafting. Contrary to these findings, here we show that full-length RLRs and their downstream signaling molecules were present in the earliest animals, suggesting that the RLR-based immune system arose with the emergence of multicellularity. Functional differentiation of RLRs occurred early in animal evolution via simple gene duplication followed by modifications of the RNA-binding pocket, many of which may have been adaptively driven. Functional analysis of human and ancestral RLRs revealed that the ancestral RLR displayed RIG-1-like RNA-binding. MDA5-like binding arose through changes in the RNA-binding pocket following the duplication of the ancestral RLR, which may have occurred either early in Bilateria or later, after deuterostomes split from protostomes. The sensitivity and specificity with which RLRs bind different RNA structures has repeatedly adapted throughout mammalian evolution, suggesting a long-term evolutionary arms race with viral RNA or other molecules.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.