ReviewWorld journal of cardiology2013
Hyponatremia in patients with heart failure.
Review in World journal of cardiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 79 citations in OpenAlex.
- Effect of tolvaptan on acute heart failure with hyponatremia--a randomized, double blind, controlled clinical trial.Indian heart journal · 2016Trial
- Association between the serum sodium-to-chloride ratio and 30-day mortality following coronary artery bypass grafting: insights from the MIMIC-IV database.BMC cardiovascular disorders · 2026Article
- Risk factors of immune checkpoint inhibitor-related cardiotoxicity: a scoping review.The oncologist · 2025Article
- Impact of hypotonic hyponatremia on outcomes in patients undergoing transcatheter aortic valve replacement: a national inpatient sample.BMC cardiovascular disorders · 2025Article
- Time to Mortality and Predictive Factors Among Adult Heart Failure Patients: Lessons From a Resource-Limited Setting.Cardiology research and practice · 2025Article
- Congestion in Heart Failure: From the Secret of a Mummy to Today's Novel Diagnostic and Therapeutic Approaches: A Comprehensive Review.Journal of clinical medicine · 2023Review
- Evidence-based hyponatremia management in liver disease.Clinical and molecular hepatology · 2023Review
- Medical Treatment in Heart Failure with Reduced Ejection Fraction: A Proposed Algorithm Based on the Patient's Electrolytes and Congestion Status.Medical sciences (Basel, Switzerland) · 2023Review
- Syndrome of inappropriate antidiuretic hormone secretion in a patient with pituitary apoplexy.BMJ case reports · 2021Article
- Hyponatremia and Renal Venous Congestion in Heart Failure Patients.Disease markers · 2021Article
- Hyponatremia in Patients with Hematologic Diseases.Journal of clinical medicine · 2020Review
- Furosemide and spironolactone doses and hyponatremia in patients with heart failure.BMC pharmacology & toxicology · 2020Observational
- Chronic hyponatremia in patients with proximal femoral fractures after low energy trauma: A retrospective study in a level-1 trauma center.Bone reports · 2020Article
- Hyponatraemia as a Predictor of Mortality in Medical Admissions in Ghana: A Comparative Study.International journal of nephrology · 2020Article
- The Use of Portal Vein Pulsatility to Differentiate Hypervolemic and Hypovolemic Hyponatremia.Case reports in critical care · 2019Article
- Hyponatremia in Heart Failure: Pathogenesis and Management.Current cardiology reviews · 2019Review
- Article
- Review
- Benefit of tolvaptan in the management of hyponatraemia in patients with diuretic-refractory congestive heart failure: the SEMI-SEC project.ESC heart failure · 2017Article
- Vasopressin Receptor Antagonists for the Correction of Hyponatremia in Chronic Heart Failure: An Underutilized Therapeutic Option in Current Clinical Practice?Journal of clinical medicine · 2016Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present review analyses the mechanisms relating heart failure and hyponatremia, describes the association of hyponatremia with the progress of disease and morbidity/mortality in heart failure patients and presents treatment options focusing on the role of arginine vasopressin (AVP)-receptor antagonists. Hyponatremia is the most common electrolyte disorder in the clinical setting and in hospitalized patients. Patients with hyponatremia may have neurologic symptoms since low sodium concentration produces brain edema, but the rapid correction of hyponatremia is also associated with major neurologic complications. Patients with heart failure often develop hyponatremia owing to the activation of many neurohormonal systems leading to decrease of sodium levels. A large number of clinical studies have associated hyponatremia with increased morbidity and mortality in patients hospitalized for heart failure or outpatients with chronic heart failure. Treatment options for hyponatremia in heart failure, such as water restriction or the use of hypertonic saline with loop diuretics, have limited efficacy. AVP-receptor antagonists increase sodium levels effectively and their use seems promising in patients with hyponatremia. However, the effects of AVP-receptor antagonists on hard outcomes in patients with heart failure and hyponatremia have not been thoroughly examined.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.