ArticleFrontiers in behavioral neuroscience2013
Opioidergic and dopaminergic manipulation of gambling tendencies: a preliminary study in male recreational gamblers.
Article in Frontiers in behavioral neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Pharmacological interventions for the treatment of disordered and problem gambling.The Cochrane database of systematic reviews · 2022Pooled it
- Opioid Antagonists for Pharmacological Treatment of Gambling Disorder: Are they Relevant?Current neuropharmacology · 2018Pooled it
- The Effect of Losses Disguised as Wins and Near Misses in Electronic Gaming Machines: A Systematic Review.Journal of gambling studies · 2017Pooled it
- Amplified Striatal Responses to Near-Miss Outcomes in Pathological Gamblers.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Trial
- Abnormal modulation of reward versus punishment learning by a dopamine D2-receptor antagonist in pathological gamblers.Psychopharmacology · 2015Trial
- Impulsivity, Critical Thinking and Near-Miss Role for Persistence in Play on a Slot Machine.Journal of gambling studies · 2025Article
- Power and Gambling: Dispositional Power Predicts Persistence on a Computerized Scratchcard Task.Journal of gambling studies · 2024Article
- Individual strategies in the rat gambling task are related to voluntary alcohol intake, but not sexual behavior, and can be modulated by naltrexone.Frontiers in psychiatry · 2022Article
- Association of Near-Miss with Two Erroneous Gambling Cognitions and Betting Intention: Evidence from Nigerian Adolescents.Journal of gambling studies · 2021Article
- The Role of Mu-Opioids for Reward and Threat Processing in Humans: Bridging the Gap from Preclinical to Clinical Opioid Drug Studies.Current addiction reports · 2021Review
- The role of the opioid system in decision making and cognitive control: A review.Cognitive, affective & behavioral neuroscience · 2019Review
- Dopamine and Gambling Disorder: Prospects for Personalized Treatment.Current addiction reports · 2019Article
- Hedonic processing in humans is mediated by an opioidergic mechanism in a mesocorticolimbic system.eLife · 2018Article
- Italian Adult Gambling Behavior: At Risk and Problem Gambler Profiles.Journal of gambling studies · 2018Article
- Increased Striatal Dopamine Synthesis Capacity in Gambling Addiction.Biological psychiatry · 2018Article
- Opioid modulation of cognitive impairment in depression.Progress in brain research · 2018Review
- Brief Intervention Within Primary Care for At-Risk Gambling: A Pilot Study.Journal of gambling studies · 2016Article
- Pharmacological treatments in gambling disorder: a qualitative review.BioMed research international · 2014Review
- Neuronal and psychological underpinnings of pathological gambling.Frontiers in behavioral neuroscience · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Gambling is characterized by cognitive distortions in the processing of chance and skill that are exacerbated in pathological gambling. Opioid and dopamine dysregulation is implicated in pathological gambling, but it is unclear whether these neurotransmitters modulate gambling distortions. The objective of the current study was to assess the effects of the opioid receptor antagonist naltrexone and the dopamine D2 receptor antagonist haloperidol on gambling behavior. Male recreational gamblers (n = 62) were assigned to receive single oral doses of naltrexone 50 mg, haloperidol 2 mg or placebo, in a parallel-groups design. At 2.5 h post-dosing, participants completed a slot machine task to elicit monetary wins, "near-misses," and a manipulation of personal choice, and a roulette game to elicit two biases in sequential processing, the gambler's fallacy and the hot hand belief. Psychophysiological responses (electrodermal activity and heart rate) were taken during the slot machine task, and plasma prolactin increase was assessed. The tasks successfully induced the gambling effects of interest. Some of these effects differed across treatment groups, although the direction of effect was not in line with our predictions. Differences were driven by the naltrexone group, which displayed a greater physiological response to wins, and marginally higher confidence ratings on winning streaks. Prolactin levels increased in the naltrexone group, but did not differ between haloperidol and placebo, implying that naltrexone but not haloperidol may have been functionally active at these doses. Our results support opioid modulation of cognition during gambling-like tasks, but did not support the more specific hypothesis that naltrexone may act to ameliorate cognitive distortions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.