ArticleFrontiers in systems neuroscience2013
The role of frontostriatal impairment in freezing of gait in Parkinson's disease.
Article in Frontiers in systems neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 93 citations in OpenAlex.
- Complex Exercises Improve Cognition in People With Parkinson's Disease and Freezing of Gait.Neurorehabilitation and neural repair · 2025Trial
- 'Recoupling' the attentional and motor control of preparatory postural adjustments to overcome freezing of gait in Parkinson's.Journal of neuroengineering and rehabilitation · 2020Trial
- Frequency-Specific EEG burst dynamics in Parkinson's Disease and freezing of gait.Journal of neurology · 2026Article
- Freezing of Gait Levodopa Response Pattern in Parkinson's Disease Provides Clues to Pathophysiology.The European journal of neuroscience · 2026Review
- Neuromodulation of Cortical Targets in Freezing of Gait.The European journal of neuroscience · 2026Review
- Supplementary motor area microstructure defines the extent of gait impairment in Parkinson's disease.NPJ Parkinson's disease · 2025Article
- The effects of dopaminergic medication and task load on trembling and akinetic freezing of gait in Parkinson's disease.Journal of neurology · 2025Article
- Cognitive Profiles Stratified by Education Using Montreal Cognitive Assessment in Parkinson's Disease Patients with Freezing of Gait.Neuropsychiatric disease and treatment · 2024Article
- Subthalamic Nucleus Activity during Cognitive Load and Gait Dysfunction in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2023Article
- Subthalamic and nigral neurons are differentially modulated during parkinsonian gait.Brain : a journal of neurology · 2023Article
- Association between Cognitive Impairment and Freezing of Gait in Patients with Parkinson's Disease.Journal of clinical medicine · 2023Article
- Differential Associations of Mobility With Fronto-Striatal Integrity and Lesion Load in Older Adults With and Without Multiple Sclerosis.Neurorehabilitation and neural repair · 2023Article
- A Novel Physical Mobility Task to Assess Freezers in Parkinson's Disease.Healthcare (Basel, Switzerland) · 2023Article
- Interval timing and midfrontal delta oscillations are impaired in Parkinson's disease patients with freezing of gait.Journal of neurology · 2022Article
- Cortico-striatal functional connectivity and cerebral small vessel disease: Contribution to mild Parkinsonian signs.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2022Article
- Abnormal neural oscillations during gait and dual-task in Parkinson's disease.Frontiers in systems neuroscience · 2022Review
- Freezing of gait in Parkinson's disease is associated with the microstructural and functional changes of globus pallidus internus.Frontiers in aging neuroscience · 2022Article
- Preconditioning prefrontal connectivity using transcranial direct current stimulation and transcranial magnetic stimulation.Frontiers in human neuroscience · 2022Article
- Imaging the neural underpinnings of freezing of gait in Parkinson's disease.NeuroImage. Clinical · 2022Review
- Reduction of falls in a rat model of PD falls by the M1 PAM TAK-071.Psychopharmacology · 2021Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Freezing of gait (FOG) is a disabling symptom of advanced Parkinson's disease (PD) that leads to an increased risk of falls and nursing home placement. Interestingly, multiple lines of evidence suggest that the manifestation of FOG is related to specific deficits in cognition, such as set shifting and the ability to process conflict-related signals. These findings are consistent with the specific patterns of abnormal cortical processing seen during functional neuroimaging experiments of FOG, implicating increased neural activation within cortical structures underlying cognition, such as the Cognitive Control Network. In addition, these studies show that freezing episodes are associated with abnormalities in the BOLD response within key structures of the basal ganglia, such as the striatum and the subthalamic nucleus. In this article, we discuss the implications of these findings on current models of freezing behavior and propose an updated model of basal ganglia impairment during FOG episodes that integrates the neural substrates of freezing from the cortex and the basal ganglia to the cognitive dysfunctions inherent in the condition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.