ReviewFrontiers in neuroscience2013
Metabolic disturbances connecting obesity and depression.
Review in Frontiers in neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 149 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
149 citing papers in PubMed, 2 syntheses or guidelines pooled it, 309 citations in OpenAlex.
- Exercise as Medicine for Mental and Substance Use Disorders: A Meta-review of the Benefits for Neuropsychiatric and Cognitive Outcomes.Sports medicine (Auckland, N.Z.) · 2020Pooled it
- Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 Clinical Guidelines for the Management of Adults with Major Depressive Disorder: Section 1. Disease Burden and Principles of Care.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2016Pooled it
- Efficacy of time restricted eating and resistance training on body composition and mood profiles among young adults with overweight/obesity: a randomized controlled trial.Journal of the International Society of Sports Nutrition · 2025Trial
- Trial
- Effect of Metabolic Syndrome on Late-Life Depression: Associations with Disease Severity and Treatment Resistance.Journal of the American Geriatrics Society · 2017Trial
- Associations of Mechanistically Partitioned Type 2 Diabetes Polygenic Risk With Psychiatric and Related Phenotypes in UK Biobank.Biological psychiatry global open science · 2026Article
- Psychological and anthropometric outcomes in preschool children exposed to antenatal maternal obesity: modelling of early life risk factors.BMJ mental health · 2026Article
- High-fat diet exposure, internal state, and reward value influence decision making during motivational conflict.Neurobiology of stress · 2026Article
- Association Between a Body Shape Index and Epilepsy Among US Adults: Potential Indirect Pathway Through Depressive Symptoms.Brain and behavior · 2026Article
- Seasonal Affective Disorder and the Microbiota-Gut-Brain Axis: Circadian Disruption, Tryptophan Metabolism, and Psychobiotic Potential ofNutrients · 2026Review
- METEOR: a data-adaptive Mendelian randomization method for powerful detection of shared and specific exposures underlying multiple outcomes.Briefings in bioinformatics · 2026Article
- Association Between Body Mass Index and Depression/Anxiety in an East Asian Population: A Mendelian Randomization Study.The Kaohsiung journal of medical sciences · 2026Article
- Fasting ghrelin as mediator between obesity and depressive symptoms: a pre-registered study.Npj mental health research · 2026Article
- Prevalence of and associated factors for depression among men seeking fertility care services at Gadarif in Eastern Sudan: a cross-sectional study.BMC public health · 2026Article
- Longitudinal co-development of mental and cardio-metabolic health from childhood to young adulthood.Journal of child psychology and psychiatry, and allied disciplines · 2026Article
- Genetic associations and candidate functional genes linking depression and obesity: a multi-omics integrative study.Frontiers in genetics · 2026Article
- Article
- Impact of Obesity, Menopause, and Depression in Women's Health: An Attempt to Decipher the Complex Relationship.Current medicinal chemistry · 2026Review
- Association between clock genes polygenic risk score for depression and obesity in a population with high burden of obesity.Nutrition & metabolism · 2025Article
- Fat-brain axis indicated by mutual impacts between body fat and brain phenotypes.Journal of translational medicine · 2025Article
89 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obesity markedly increases the odds of developing depression. Depressed mood not only impairs motivation, quality of life and overall functioning but also increases the risks of obesity complications. Abdominal obesity is a better predictor of depression and anxiety risk than overall adipose mass. A growing amount of research suggests that metabolic abnormalities stemming from central obesity that lead to metabolic disease may also be responsible for the increased incidence of depression in obesity. As reviewed here, a higher mass of dysfunctional adipose tissue is associated with several metabolic disturbances that are either directly or indirectly implicated in the control of emotions and mood. To better comprehend the development of depression in obesity, this review pulls together select findings addressing the link between adiposity, diet and negative emotional states and discusses the evidence that alterations in glucocorticoids, adipose-derived hormones, insulin and inflammatory signaling that are characteristic of central obesity may be involved.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.