Evidence map›Paper›PMID 24109201›Full record

ReviewNature and science of sleep2013

Obstructive sleep apnea in children: a critical update.

Hui-Leng Tan, David Gozal, Leila Kheirandish-Gozal

4 registry-linked trialsOpen access · goldAbstract readReview
In one paragraph

Review in Nature and science of sleep, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 122 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
122citing papers in PubMed, 9 pooled it
10.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02447614 completednot on this mapstarted 2014, after this paper: background citation

Follow-up Studies of PS and OSAHS in Chinese Children

Typeobservational_patient_registrySponsorBeijing Children's HospitalRan2014 to 2022Enrolled500ConditionsObstructive Sleep Apnea SyndromeArmsAdenotonsillectomy, Conservative treatment, no treatment
NCT03449550 nacompletednot on this mapstarted 2015, after this paper: background citation

Validity and Cost-effectiveness Analysis of a Home Respiratory Polygraphy for the Diagnosis of Obstructive Sleep Apnea in Children (DINISAS)

TypeinterventionalSponsorHospital Universitario ArabaRan2015 to 2020Enrolled320ConditionsObstructive Sleep ApneaArmsHome Respiratory Polygraphy (HRP), Standard Polysomnography (PSG)
NCT04328402 completednot on this mapstarted 2020, after this paper: background citation

Factors Correlated With Obstructive Sleep Apnea in Children and Adolescents Diagnosed by Polysomnography: Cross-sectional Study

TypeobservationalSponsorFederal University of PelotasRan2020 to 2021Enrolled187ConditionsObstructive Sleep Apnea of ChildArmsPolysomnography
NCT05368077 nacompletednot on this mapstarted 2022, after this paper: background citation

Brain Changes in Pediatric Obstructive Sleep Apnea

TypeinterventionalSponsorUniversity of California, Los AngelesRan2022 to 2024Enrolled56ConditionsPediatric Obstructive Sleep ApneaArmsAdenotonsillectomy
3 · Its place in the literature

Who cites it

122 citing papers in PubMed, 9 syntheses or guidelines pooled it, 255 citations in OpenAlex.

  1. Pooled it
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  3. Current role of artificial intelligence and machine learning: is their application feasible in pediatric upper airway obstructive disorders?European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Pooled it
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  9. Diagnostic capability of biological markers in assessment of obstructive sleep apnea: a systematic review and meta-analysis.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2015
    Pooled it
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62 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Hui-Leng TanSections of Pediatric Sleep Medicine and Pediatric Pulmonology, Department of Pediatrics, Comer Children's Hospital, Pritzker School of Medicine, The University of Chicago, Chicago, IL, USA ; Department of Paediatric Respiratory Medicine, Royal Brompton Hospital, London, UK.
David Gozal
Leila Kheirandish-Gozal
Pulmonary Associates · USRoyal Brompton Hospital · GB

Funding

NEUROCOGNITIVE FUNCTION IN SNORING CHILDRENR01HL065270 · NHLBI · UNIVERSITY OF LOUISVILLE · PI GOZAL, DAVID · 1999 to 2014
$5.0M
Oxidative stress in a murine model of sleep apneaR01HL086662 · NHLBI · UNIVERSITY OF LOUISVILLE · PI GOZAL, DAVID · 2008 to 2012
$1.9M
Validation of Urinary Biomarkers in Diagnosis of Pediatric OSAP50HL107160 · NHLBI · UNIVERSITY OF CHICAGO · PI GOZAL, DAVID · 2011 to 2012
$923k
NHLBI NIH HHS P50 HL107160NHLBI NIH HHS R01 HL065270NHLBI NIH HHS R01 HL086662
6 · The paper itself

Abstract

Obstructive sleep apnea (OSA) in children is a highly prevalent disorder caused by a conglomeration of complex pathophysiological processes, leading to recurrent upper airway dysfunction during sleep. The clinical relevance of OSA resides in its association with significant morbidities that affect the cardiovascular, neurocognitive, and metabolic systems. The American Academy of Pediatrics recently reiterated its recommendations that children with symptoms and signs suggestive of OSA should be investigated with polysomnography (PSG), and treated accordingly. However, treatment decisions should not only be guided by PSG results, but should also integrate the magnitude of symptoms and the presence or absence of risk factors and signs of OSA morbidity. The first-line therapy in children with adenotonsillar hypertrophy is adenotonsillectomy, although there is increasing evidence that medical therapy, in the form of intranasal steroids or montelukast, may be considered in mild OSA. In this review, we delineate the major concepts regarding the pathophysiology of OSA, its morbidity, diagnosis, and treatment.

Indexed as

adenotonsillar hypertrophymorbiditypathophysiologypediatric sleep disordered breathingpolysomnographytreatment

Identifiers

PMID24109201
PMCPMC3792928
OpenAlexW2169308965

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.