ArticleProceedings of the National Academy of Sciences of the United States of America1985
The sequence of a type II keratin gene expressed in human skin: conservation of structure among all intermediate filament genes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1985. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
- Identification of reptilian genes encoding hair keratin-like proteins suggests a new scenario for the evolutionary origin of hair.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Cloning, mapping and expression analysis of barley MADS-box genes.Plant molecular biology · 2000Article
- Intermediate filament expression in prostate cancer.Cancer metastasis reviews · 1996Review
- A novel MADS-box gene of potato (Solanum tuberosum L.) expressed during the early stages of tuberization.Plant molecular biology · 1996Article
- Onset of re-epithelialization after skin injury correlates with a reorganization of keratin filaments in wound edge keratinocytes: defining a potential role for keratin 16.The Journal of cell biology · 1996Article
- ZEMa, a member of a novel group of MADS box genes, is alternatively spliced in maize endosperm.Nucleic acids research · 1995Article
- The Arabidopsis MADS-box gene AGL3 is widely expressed and encodes a sequence-specific DNA-binding protein.Plant molecular biology · 1995Article
- A 5'-upstream region of a bovine keratin 6 gene confers tissue-specific expression and hyperproliferation-related induction in transgenic mice.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Eight genes and alternative RNA processing pathways generate an unexpectedly large diversity of cytoplasmic intermediate filament proteins in the nematode Caenorhabditis elegans.The EMBO journal · 1994Article
- A review of intermediate filament biology and their use in pathologic diagnosis.Molecular biology reports · 1994Review
- Expression of the carcinoma-associated keratin K6 and the role of AP-1 proto-oncoproteins.Gene expression · 1993Article
- Differential expression of two MADS box genes in wild-type and mutant petunia flowers.The Plant cell · 1992Article
- Transcription factor AP2 and its role in epidermal-specific gene expression.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
- Epidermal differentiation: the bare essentials.The Journal of cell biology · 1990Review
- Structure of an invertebrate gene encoding cytoplasmic intermediate filament (IF) proteins: implications for the origin and the diversification of IF proteins.The EMBO journal · 1990Article
- Nuclear receptors for retinoic acid and thyroid hormone regulate transcription of keratin genes.Cell regulation · 1990Article
- TGF-beta and retinoic acid: regulators of growth and modifiers of differentiation in human epidermal cells.Cell regulation · 1990Article
- Isolation, sequence, and expression of a human keratin K5 gene: transcriptional regulation of keratins and insights into pairwise control.Molecular and cellular biology · 1989Article
- The amino acid sequence of component 7c, a type II intermediate-filament protein from wool.The Biochemical journal · 1989Article
- Isolation, sequence, and differential expression of a human K7 gene in simple epithelial cells.The Journal of cell biology · 1988Article
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Authors and funding
3 authors.
Funding
Abstract
We report here the coding sequence of the gene for a 56-kDa type II keratin (designated K6b). Using a subclone specific for a unique 3' noncoding region of the encoded mRNA, we have shown that this gene is one of at least two 56-kDa keratin genes expressed in abundance in human epidermis. Segmenting the coding portion of this gene are eight introns, six of which are identically positioned with those of a distantly related type III intermediate filament gene (vimentin), and five of which are identically positioned with those of a distantly related type I gene (50-kDa keratin). These results indicate a common ancestral origin for all three classes of intermediate filament genes. All of the highly conserved intron positions are located within, but do not demarcate, the four central alpha-helical domains common to all intermediate filament polypeptides, suggesting that these genes were probably not created piecemeal by recombination-mediated linkage of separate structural domains as they presently are known.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.