ArticleMovement disorders : official journal of the Movement Disorder Society2013
Specific splice variants are associated with Parkinson's disease.
Article in Movement disorders : official journal of the Movement Disorder Society, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 21 citations in OpenAlex.
- The Exon-Based Transcriptomic Analysis of Parkinson's Disease.Biomolecules · 2025Article
- The Potential ofGenes · 2023Article
- Mining genetic and transcriptomic data using machine learning approaches in Parkinson's disease.NPJ Parkinson's disease · 2020Review
- Upgraded Methodology for the Development of Early Diagnosis of Parkinson's Disease Based on Searching Blood Markers in Patients and Experimental Models.Molecular neurobiology · 2019Article
- Computational systems biology approaches for Parkinson's disease.Cell and tissue research · 2018Review
- Evaluation of RNA Blood Biomarkers in the Parkinson's Disease Biomarkers Program.Frontiers in aging neuroscience · 2018Article
- Assessment of brain reference genes for RT-qPCR studies in neurodegenerative diseases.Scientific reports · 2016Article
- Integrative transcriptomic meta-analysis of Parkinson's disease and depression identifies NAMPT as a potential blood biomarker for de novo Parkinson's disease.Scientific reports · 2016Article
- Splicing: is there an alternative contribution to Parkinson's disease?Neurogenetics · 2015Review
- Reply to Toker and Pavlidis: Blood biomarkers for Parkinson's disease.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Network-based metaanalysis identifies HNF4A and PTBP1 as longitudinally dynamic biomarkers for Parkinson's disease.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Blood Biomarkers Associated with Cognitive Decline in Early Stage and Drug-Naive Parkinson's Disease Patients.PloS one · 2015Observational
- Current Challenges Towards the Development of a Blood Test for Parkinson's Disease.Diagnostics (Basel, Switzerland) · 2014Review
- Network analysis identifies SOD2 mRNA as a potential biomarker for Parkinson's disease.PloS one · 2014Article
- Integrative network analysis unveils convergent molecular pathways in Parkinson's disease and diabetes.PloS one · 2013Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundDiagnosis of Parkinson's disease (PD) currently relies on assessment of motor symptoms. Recently, sensitive, specific, and readily available splice variant-specific biomarkers were identified in peripheral blood from participants in the Diagnostic and Prognostic Biomarkers in Parkinson Disease study.
methodsHere we test for an association between candidate splice variant biomarkers and PD in blood of an independent population of cases and controls nested in the Harvard NeuroDiscovery Center Biomarker Study.
resultsExpression of 7 out of 13 candidate biomarkers was dysregulated in whole cellular blood of patients with PD.
conclusionsThese results support the view that differential expression of a subset of splice-variant markers in blood is associated with PD. Further evaluation in untreated, de novo patients and at-risk subjects is warranted.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.