ArticleJournal of immunology (Baltimore, Md. : 1950)2013
MAIT recognition of a stimulatory bacterial antigen bound to MR1.
Article in Journal of immunology (Baltimore, Md. : 1950), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
47 citing papers in PubMed, 80 citations in OpenAlex.
- Microbe-specific unconventional T cells induce human neutrophil differentiation into antigen cross-presenting cells.Journal of immunology (Baltimore, Md. : 1950) · 2014Trial
- Molecular Insights Into MR1-Mediated T Cell Immunity: Lessons Learned and Unanswered Questions.Immunological reviews · 2025Review
- Multiple Isomers of Photolumazine V Bind MR1 and Differentially Activate MAIT Cells.Journal of immunology (Baltimore, Md. : 1950) · 2024Article
- Promiscuous recognition of MR1 drives self-reactive mucosal-associated invariant T cell responses.The Journal of experimental medicine · 2023Article
- Molecular insights into metabolite antigen recognition by mucosal-associated invariant T cells.Current opinion in immunology · 2023Review
- Article
- Identification of T cell antigens in the 21st century, as difficult as ever.Seminars in immunology · 2022Review
- Differential antigenic requirements by diverse MR1-restricted T cells.Immunology and cell biology · 2022Article
- Engineering soluble T-cell receptors for therapy.The FEBS journal · 2021Review
- Diverse Mucosal-Associated Invariant TCR Usage in HIV Infection.ImmunoHorizons · 2021Article
- The MAIT TCRβ chain contributes to discrimination of microbial ligand.Immunology and cell biology · 2020Article
- Ligand-dependent downregulation of MR1 cell surface expression.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Covering All the Bases: Complementary MR1 Antigen Presentation Pathways Sample Diverse Antigens and Intracellular Compartments.Frontiers in immunology · 2020Review
- TCR and Inflammatory Signals Tune Human MAIT Cells to Exert Specific Tissue Repair and Effector Functions.Cell reports · 2019Article
- Characterization of major histocompatibility complex-related molecule 1 sequence variants in non-human primates.Immunogenetics · 2019Article
- MR1-dependent antigen presentation.Seminars in cell & developmental biology · 2018Review
- Tuning of human MAIT cell activation by commensal bacteria species and MR1-dependent T-cell presentation.Mucosal immunology · 2018Article
- Role of MAIT cells in pulmonary bacterial infection.Molecular immunology · 2018Review
- MR1 displays the microbial metabolome driving selective MR1-restricted T cell receptor usage.Science immunology · 2018Article
- Modulation of bacterial metabolism by the microenvironment controls MAIT cell stimulation.Mucosal immunology · 2018Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
MR1-restricted mucosal-associated invariant T (MAIT) cells represent a subpopulation of αβ T cells with innate-like properties and limited TCR diversity. MAIT cells are of interest because of their reactivity against bacterial and yeast species, suggesting that they play a role in defense against pathogenic microbes. Despite the advances in understanding MAIT cell biology, the molecular and structural basis behind their ability to detect MR1-Ag complexes is unclear. In this study, we present our structural and biochemical characterization of MAIT TCR engagement of MR1 presenting an Escherichia coli-derived stimulatory ligand, rRL-6-CH2OH, previously found in Salmonella typhimurium. We show a clear enhancement of MAIT TCR binding to MR1 due to the presentation of this ligand. Our structure of a MAIT TCR/MR1/rRL-6-CH2OH complex shows an evolutionarily conserved binding orientation, with a clear role for both the CDR3α and CDR3β loops in recognizing the rRL-6-CH2OH stimulatory ligand. We also present two additional xenoreactive MAIT TCR/MR1 complexes that recapitulate the docking orientation documented previously, despite having variation in the CDR2β and CDR3β loop sequences. Our data support a model by which MAIT TCRs engage MR1 in a conserved fashion, with their binding affinities modulated by the nature of the MR1-presented Ag or diversity introduced by alternate Vβ usage or CDR3β sequences.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.