Trial reportBirth defects research. Part A, Clinical and molecular teratology2013
Traffic-related air pollution and selected birth defects in the San Joaquin Valley of California.
Trial report in Birth defects research. Part A, Clinical and molecular teratology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pooled it
- Effects of air pollution on the risk of congenital anomalies: a systematic review and meta-analysis.International journal of environmental research and public health · 2014Pooled it
- Wildland fire smoke and birth defects in California.Journal of exposure science & environmental epidemiology · 2026Article
- Article
- How Can Outdoor Air Pollutants Adversely Affect the Women's Fertility? Systematic Review.Advanced biomedical research · 2024Review
- US air pollution is associated with increased incidence of non-syndromic cleft lip/palate.Journal of plastic, reconstructive & aesthetic surgery : JPRAS · 2024Article
- Association Between Maternal Exposure to SOInternational journal of public health · 2022Article
- First trimester exposure to ambient gaseous air pollutants and risk of orofacial clefts: a case-control study in Changsha, China.BMC oral health · 2021Article
- Evidence of Low-Habitat Contamination Using Feathers of Three Heron Species as a Biomonitor of Inorganic Elemental Pollution.International journal of environmental research and public health · 2020Article
- Maternal exposure to outdoor air pollution and congenital limb deficiencies in the National Birth Defects Prevention Study.Environmental research · 2019Article
- Potential selection bias associated with using geocoded birth records for epidemiologic research.Annals of epidemiology · 2016Article
- Does maternal exposure to benzene and PM10 during pregnancy increase the risk of congenital anomalies? A population-based case-control study.The Science of the total environment · 2016Article
- Autism spectrum disorder prevalence and proximity to industrial facilities releasing arsenic, lead or mercury.The Science of the total environment · 2015Article
- Can cell proliferation of umbilical cord blood cells reflect environmental exposures?SpringerPlus · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundBirth defects are a leading cause of infant morbidity and mortality. Studies suggest associations between environmental contaminants and some structural anomalies, although evidence is limited and several anomalies have not been investigated previously.
methodsWe used data from the California Center of the National Birth Defects Prevention Study and the Children's Health and Air Pollution Study to estimate the odds of 26 congenital birth defect phenotypes with respect to quartiles of seven ambient air pollutant and traffic exposures in California during the first 2 months of pregnancy, 1997 to 2006 (874 cases and 849 controls). We calculated odds ratios (adjusted for maternal race/ethnicity, education, and vitamin use; aOR) for 11 phenotypes that had at least 40 cases.
resultsFew odds ratios had confidence intervals that did not include 1.0. Odds of esophageal atresia were increased for the highest versus lowest of traffic density (aOR = 2.8, 95% confidence interval [CI], 1.1-7.4) and PM10 exposure (aOR 4.9; 95% CI, 1.4-17.2). PM₁₀ was associated with a decreased risk of hydrocephaly (aOR= 0.3; 95% CI, 0.1-0.9) and CO with decreased risk of anotia/microtia (aOR = 0.4; 95% CI, 0.2-0.8) and transverse limb deficiency (aOR = 0.4; 95% CI, 0.2-0.9), again reflecting highest versus lowest quartile comparisons.
conclusionMost analyses showed no substantive association between air pollution and the selected birth defects with few exceptions of mixed results.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.