ArticleInternational journal of molecular sciences2013
N,N'-alkylated Imidazolium-derivatives act as quorum-sensing inhibitors targeting the Pectobacterium atrosepticum-induced symptoms on potato tubers.
Article in International journal of molecular sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 15 citations in OpenAlex.
- Bringing Antimicrobial Strategies to a New Level: The Quorum Sensing System as a Target to ControlLife (Basel, Switzerland) · 2022Review
- Screening strategies for quorum sensing inhibitors in combating bacterial infections.Journal of pharmaceutical analysis · 2022Review
- Heterocyclic Chemistry Applied to the Design ofMolecules (Basel, Switzerland) · 2021Review
- Quorum Sensing Inhibitors: Curbing Pathogenic Infections through Inhibition of Bacterial Communication.Iranian journal of pharmaceutical research : IJPR · 2021Review
- Saline Environments as a Source of Potential Quorum Sensing Disruptors to Control Bacterial Infections: A Review.Marine drugs · 2019Review
- Biocontrol of the Potato Blackleg and Soft Rot Diseases Caused by Dickeya dianthicola.Applied and environmental microbiology · 2016Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bacteria belonging to the Pectobacterium genus are the causative agents of the blackleg and soft-rot diseases that affect potato plants and tubers worldwide. In Pectobacterium, the expression of the virulence genes is controlled by quorum-sensing (QS) and N-acylhomoserine lactones (AHLs). In this work, we screened a chemical library of QS-inhibitors (QSIs) and AHL-analogs to find novel QSIs targeting the virulence of Pectobacterium. Four N,N'-bisalkylated imidazolium salts were identified as QSIs; they were active at the µM range. In potato tuber assays, two of them were able to decrease the severity of the symptoms provoked by P. atrosepticum. This work extends the range of the QSIs acting on the Pectobacterium-induced soft-rot disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.