ArticleProceedings of the National Academy of Sciences of the United States of America2013
Lanthanide near infrared imaging in living cells with Yb3+ nano metal organic frameworks.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed, 284 citations in OpenAlex.
- A Cu-Based Near-IR Active MOF with an Ion-Pair Guest Exhibiting Versatile and Selective Gas-Solid Reactivity.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Advances in metal-organic frameworks (MOFs) for nanotheranostics: from targeted drug delivery to multimodal imaging.Mikrochimica acta · 2026Review
- Article
- Synthesis and Purification of [Eu(BA)Nanomaterials (Basel, Switzerland) · 2025Article
- Dual-Antenna Trimetallic Lanthanide Complexes for Enhanced Near-Infrared Luminescence.Chemistry, an Asian journal · 2025Article
- Mechano-chemical encapsulation of gemcitabine hydrochloride on metal-organic framework, preparation of shaped pellets, delayed drug release, and time-dependent toxicity to PANC-1 cancer cells.Journal of drug delivery science and technology · 2025Article
- Double-Decker Platinum Complexes: From Visible to NIR-II Luminescence.Inorganic chemistry · 2025Article
- Recent Advancements in Metal-Organic Framework-Based Microfluidic Chips for Biomedical Applications.Micromachines · 2025Review
- A Near-Infrared-II Luminescent and Photoactive Vanadium(II) Complex with a 760 ns Excited State Lifetime.Journal of the American Chemical Society · 2025Article
- Luminescent Lanthanides in Biorelated Applications: From Molecules to Nanoparticles and Diagnostic Probes to Therapeutics.Chemical reviews · 2025Review
- Understanding Structural Isomerism in Organoiridium Picolinamidate Complexes and its Consequences on Reactivity and Biological Properties.Inorganic chemistry frontiers · 2024Article
- Luminescence Probes in Bio-Applications: From Principle to Practice.Biosensors · 2024Review
- NIR-II Emission from Cyclometalated Dinuclear Pt(III) Complexes.Inorganic chemistry · 2024Article
- Review
- Nanoparticles for Thrombus Diagnosis and Therapy: Emerging Trends in Thrombus-theranostics.Nanotheranostics · 2024Review
- Near-infrared magnetic core-shell nanoparticles based on lanthanide metal-organic frameworks as a ratiometric felodipine sensing platform.Communications chemistry · 2023Article
- Heterometallic lanthanide complexes with site-specific binding that enable simultaneous visible and NIR-emission.Frontiers in chemistry · 2023Article
- Ratiometric optical probes for biosensing.Theranostics · 2023Review
- Sensitization Pathways in NIR-Emitting Yb(III) Complexes Bearing 0, +1, +2, or +3 Charges.Journal of the American Chemical Society · 2022Article
- Application of MOF-based nanotherapeutics in light-mediated cancer diagnosis and therapy.Journal of nanobiotechnology · 2022Review
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have created unique near-infrared (NIR)-emitting nanoscale metal-organic frameworks (nano-MOFs) incorporating a high density of Yb(3+) lanthanide cations and sensitizers derived from phenylene. We establish here that these nano-MOFs can be incorporated into living cells for NIR imaging. Specifically, we introduce bulk and nano-Yb-phenylenevinylenedicarboxylate-3 (nano-Yb-PVDC-3), a unique MOF based on a PVDC sensitizer-ligand and Yb(3+) NIR-emitting lanthanide cations. This material has been structurally characterized, its stability in various media has been assessed, and its luminescent properties have been studied. We demonstrate that it is stable in certain specific biological media, does not photobleach, and has an IC50 of 100 μg/mL, which is sufficient to allow live cell imaging. Confocal microscopy and inductively coupled plasma measurements reveal that nano-Yb-PVDC-3 can be internalized by cells with a cytoplasmic localization. Despite its relatively low quantum yield, nano-Yb-PVDC-3 emits a sufficient number of photons per unit volume to serve as a NIR-emitting reporter for imaging living HeLa and NIH 3T3 cells. NIR microscopy allows for highly efficient discrimination between the nano-MOF emission signal and the cellular autofluorescence arising from biological material. This work represents a demonstration of the possibility of using NIR lanthanide emission for biological imaging applications in living cells with single-photon excitation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.