Evidence map›Paper›PMID 24108316›Full record

Trial reportThe Journal of clinical endocrinology and metabolism2013

A randomized study on the effect of vitamin D₃ supplementation on skeletal muscle morphology and vitamin D receptor concentration in older women.

Lisa Ceglia, Sathit Niramitmahapanya, Mauricio da Silva Morais, Donato A Rivas, Susan S Harris, Heike Bischoff-Ferrari, Roger A Fielding, Bess Dawson-Hughes

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of clinical endocrinology and metabolism, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 128 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
128citing papers in PubMed, 12 pooled it
13.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

128 citing papers in PubMed, 12 syntheses or guidelines pooled it, 253 citations in OpenAlex.

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  11. Vitamin D supplementation and its influence on muscle strength and mobility in community-dwelling older persons: a systematic review and meta-analysis.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2017
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68 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Lisa CegliaMD, MS, Division of Endocrinology, Diabetes, and Metabolism, Tufts Medical Center, 800 Washington Street, Box 268, Boston, MA 02111. lisa.ceglia@tufts.edu.
Sathit Niramitmahapanya
Mauricio da Silva Morais
Donato A Rivas
Susan S Harris
Heike Bischoff-Ferrari
Roger A Fielding
Bess Dawson-Hughes
Jean Mayer Human Nutrition Research Center on Aging · USTufts Medical Center · USRangsit University · THUniversity of Zurich · CH

Funding

TUFTS--FIELDINGP30AG031679 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI Ravi Jasuja · 2008 to 2026
$23.9M
Tufts Clinical and Translational Science Institute (K12)KL2RR025751 · NCRR · TUFTS UNIVERSITY BOSTON · PI SELKER, HARRY P. · 2008 to 2011
$596k
NCRR NIH HHS KL2 RR025751NIA NIH HHS P30 AG031679NIA NIH HHS P30AG031679
6 · The paper itself

Abstract

contextStudies examining whether vitamin D supplementation increases muscle mass or muscle-specific vitamin D receptor (VDR) concentration are lacking.

objectiveOur objective was to determine whether vitamin D₃ 4000 IU/d alters muscle fiber cross-sectional area (FCSA) and intramyonuclear VDR concentration over 4 months. DESIGN AND

settingThis was a randomized, double-blind, placebo-controlled study in a single center.

participantsParticipants were 21 mobility-limited women (aged ≥ 65 years) with serum 25-hydroxyvitamin D (25OHD) levels of 22.5 to 60 nmol/L.

main outcome measuresBaseline and 4-month FCSA and intramyonuclear VDR were measured from vastus lateralis muscle cross-sections probed for muscle fiber type (I/IIa/IIx) and VDR using immunofluorescence.

resultsAt baseline, mean (±SD) age was 78 ± 5 years; body mass index was 27 ± 5 kg/m², 25OHD was 46.3 ± 9.5 nmol/L, and a short physical performance battery score was 7.95 ± 1.57 out of 12. At 4 months, 25OHD level was 52.5 ± 17.1 (placebo) vs 80.0 ± 11.5 nmol/L (vitamin D [VD]; P < .01), and change in 25OHD level was strongly associated with percent change in intramyonuclear VDR concentration-independent of group (r = 0.87, P < .001). By treatment group, percent change in intramyonuclear VDR concentration was 7.8% ± 18.2% (placebo) vs 29.7% ± 11.7% (VD; P = .03) with a more pronounced group difference in type II vs I fibers. Percent change in total (type I/II) FCSA was -7.4% ± 18.9% (placebo) vs 10.6% ± 20.0% (VD; P = .048).

conclusionVitamin D₃ supplementation increased intramyonuclear VDR concentration by 30% and increased muscle fiber size by 10% in older, mobility-limited, vitamin D-insufficient women. Further work is needed to determine whether the observed effect of vitamin D on fiber size is mediated by the VDR and to identify which signaling pathways are involved.

Indexed as

AgingDietary SupplementsMuscle DevelopmentAgedAged, 80 and overAnatomy, Cross-SectionalCalcifediolCholecalciferolCohort StudiesDouble-Blind MethodFemaleGeriatric AssessmentHumansMobility LimitationMuscle Fibers, Fast-TwitchMuscle Fibers, Slow-TwitchCalcifediolCholecalciferolReceptors, CalcitriolVDR protein, human

Identifiers

PMID24108316
PMCPMC3849671
OpenAlexW2008744282

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.