ReviewChannels (Austin, Tex.)
The STIM1/Orai signaling machinery.
Review in Channels (Austin, Tex.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 46 citations in OpenAlex.
- Evolutionarily conserved hydrophobicity and sterics in TM3/TM4 balance Orai1 pore opening.Protein science : a publication of the Protein Society · 2026Article
- Review of the clinical electrooculogram - Part 1: Mechanism of the Light-Rise.Documenta ophthalmologica. Advances in ophthalmology · 2026Review
- Proteolytically Activated CRAC Effectors through Designed Intramolecular Inhibition.ACS synthetic biology · 2022Article
- Science CommuniCaCells · 2022Review
- Isoform-Specific Properties of Orai Homologues in Activation, Downstream Signaling, Physiology and Pathophysiology.International journal of molecular sciences · 2021Review
- Stromal-Interacting Molecule 1 (Stim1)/Orai1 Modulates Endothelial Permeability in Ventilator-Induced Lung Injury.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- Cholesterol modulates the cellular localization of Orai1 channels and its disposition among membrane domains.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2017Article
- STIM1 Phosphorylation at Y361 Recruits Orai1 to STIM1 Puncta and Induces CaScientific reports · 2017Article
- Role of STIM1 in the surface expression of SARAF.Channels (Austin, Tex.) · 2017Article
- Orai1 and Orai3 Mediate Store-Operated Calcium Entry Contributing to Neuronal Excitability in Dorsal Root Ganglion Neurons.Frontiers in cellular neuroscience · 2017Article
- Calcium Signaling Is Dispensable for Receptor Regulation of Endothelial Barrier Function.The Journal of biological chemistry · 2016Article
- STIMs and Orai1 regulate cytokine production in spinal astrocytes.Journal of neuroinflammation · 2016Article
- Molecular mechanisms of STIM/Orai communication.American journal of physiology. Cell physiology · 2016Review
- Altered expression of stromal interaction molecule (STIM)-calcium release-activated calcium channel protein (ORAI) and inositol 1,4,5-trisphosphate receptors (IP3Rs) in cancer: will they become a new battlefield for oncotherapy?Chinese journal of cancer · 2016Review
- Junctophilin-4, a component of the endoplasmic reticulum-plasma membrane junctions, regulates Ca2+ dynamics in T cells.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Calcium Influx of Mast Cells Is Inhibited by Aptamers Targeting the First Extracellular Domain of Orai1.PloS one · 2016Article
- STIMATE reveals a STIM1 transitional state.Nature cell biology · 2015Article
- Ca²⁺ microdomains organized by junctophilins.Cell calcium · 2015Review
- STIM and Orai1 Variants in Store-Operated Calcium Entry.Frontiers in pharmacology · 2015Review
- A coiled-coil clamp controls both conformation and clustering of stromal interaction molecule 1 (STIM1).The Journal of biological chemistry · 2014Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Ca(2+) influx via store-operated Ca(2+) release activated Ca(2+) (CRAC) channels represents a main signaling pathway for T-cell activation as well as mast-cell degranulation. The ER-located Ca(2+)-sensor, STIM1 and the Ca(2+)-selective ion pore, Orai1 in the membrane are sufficient to fully reconstitute CRAC currents. Their identification, but even more the recent structural resolution of both proteins by X-ray crystallography has substantially advanced the understanding of the activation mechanism of CRAC channels. In this review, we provide a detailed description of the STIM1/Orai1 signaling pathway thereby focusing on the critical domains mediating both, intra- as well as intermolecular interactions and on the ion permeation pathway. Based on the results of functional studies as well as the recently published crystal structures, we portray a mechanistic view of the steps in the CRAC channel signaling cascade ranging from STIM1 oligomerization over STIM1-Orai1 coupling to the ultimate Orai1 channel activation and permeation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.