ArticleScience translational medicine2013
A new PERKspective on neurodegeneration.
Article in Science translational medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- Model Identifies Genetic Predisposition of Alzheimer's Disease as Key Decider in Cell Susceptibility to Stress.International journal of molecular sciences · 2021Article
- The unfolded protein response is activated in the olfactory system in Alzheimer's disease.Acta neuropathologica communications · 2020Article
- PERK Pathway Activation Promotes Intracerebral Hemorrhage Induced Secondary Brain Injury by Inducing Neuronal Apoptosis BothFrontiers in neuroscience · 2018Article
- The eIF2-alpha kinase HRI: a potential target beyond the red blood cell.Expert opinion on therapeutic targets · 2017Review
- Dual leucine zipper kinase-dependent PERK activation contributes to neuronal degeneration following insult.eLife · 2017Article
- Protein Homeostasis in Amyotrophic Lateral Sclerosis: Therapeutic Opportunities?Frontiers in molecular neuroscience · 2017Review
- The unfolded protein response in neurodegenerative diseases: a neuropathological perspective.Acta neuropathologica · 2015Review
- The unfolded protein response mediates reversible tau phosphorylation induced by metabolic stress.Cell death & disease · 2014Article
- Altering endoplasmic reticulum stress in a model of blast-induced traumatic brain injury controls cellular fate and ameliorates neuropsychiatric symptoms.Frontiers in cellular neuroscience · 2014Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Targeting stress-induced kinases that regulate protein synthesis may be a new therapeutic strategy for treating neurodegenerative diseases.
Indexed as
Identifiers
24107775What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.