ArticleAmerican journal of physiology. Renal physiology2013
Gamma subunit second transmembrane domain contributes to epithelial sodium channel gating and amiloride block.
Article in American journal of physiology. Renal physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Acid-sensing ion channel 2a assembles with epithelial NaThe Journal of biological chemistry · 2026Article
- The Epithelial Sodium Channel-An Underestimated Drug Target.International journal of molecular sciences · 2023Review
- Kidney ion handling genes and their interaction in blood pressure control.Bioscience reports · 2022Review
- Hypertension: Do Inflammation and Immunity Hold the Key to Solving this Epidemic?Circulation research · 2021Review
- ENaC in Salt-Sensitive Hypertension: Kidney and Beyond.Current hypertension reports · 2020Review
- New insights regarding epithelial Na+ channel regulation and its role in the kidney, immune system and vasculature.Current opinion in nephrology and hypertension · 2019Review
- Epithelial Sodium Channel in Aldosterone-Induced Endothelium Stiffness and Aortic Dysfunction.Hypertension (Dallas, Tex. : 1979) · 2018Article
- Pore-lining residues of MEC-4 and MEC-10 channel subunits tune theThe Journal of biological chemistry · 2018Article
- Plasma Potassium Determines NCC Abundance in Adult Kidney-SpecificJournal of the American Society of Nephrology : JASN · 2018Article
- Estrogen increases ENaC activity via PKCδ signaling in renal cortical collecting duct cells.Physiological reports · 2014Article
- Deletion of α-subunit exon 11 of the epithelial Na+ channel reveals a regulatory module.American journal of physiology. Renal physiology · 2014Article
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Authors and funding
2 authors.
Funding
Abstract
The epithelial sodium channel (ENaC) is comprised of three homologous subunits. Channels composed solely of α- and β-subunits (αβ-channels) exhibit a very high open probability (Po) and reduced sensitivity to amiloride, in contrast to channels composed of α- and γ-subunits or of all three subunits (i.e., αγ- and αβγ-channels). A mutant channel comprised of α- and β-subunits, and a chimeric γ-subunit where the region immediately preceding (β12 and wrist) and encompassing the second transmembrane domain (TM2) was replaced with the corresponding region of the β-subunit (γ-βTM2), displayed characteristics reminiscent of αβ-channels, including a reduced amiloride potency of block and a loss of Na(+) self-inhibition (reflecting an increased Po). Substitutions at key pore-lining residues of the γ-βTM2 chimera enhanced the Na(+) self-inhibition response, whereas key γ-subunit substitutions reduced the response. Furthermore, multiple sites within the TM2 domain of the γ-subunit were required to confer high amiloride potency. In summary, we have identified novel pore-lining residues of the γ-subunit of ENaC that are important for proper channel gating and its interaction with amiloride.
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