ArticleJournal of the American Chemical Society2013
Re-examining the size/charge paradigm: differing in vivo characteristics of size- and charge-matched mesoporous silica nanoparticles.
Article in Journal of the American Chemical Society, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systemic review on development of mesoporous nanoparticles as a vehicle for transdermal drug delivery.Nanotheranostics · 2023Pooled it
- The rationality guidance index: a framework for reducing redundancy in nanomedicine innovation.Nanomedicine (London, England) · 2025Review
- Tailored Mesoporous Silica Nanoparticles and the Chick Chorioallantoic Membrane: A Promising Strategy and Model for Efficient Blood-Brain Barrier Crossing.ACS applied materials & interfaces · 2025Article
- Article
- Graphene Oxide Nanosheets Toxicity in Mice Is Dependent on Protein Corona Composition and Host Immunity.ACS nano · 2024Article
- Nanotherapeutic Heterogeneity: Sources, Effects, and Solutions.Small (Weinheim an der Bergstrasse, Germany) · 2024Review
- Recent Advances in Mesoporous Silica Nanoparticle-Mediated Drug Delivery for Breast Cancer Treatment.Pharmaceutics · 2023Review
- A mathematical model to predict nanomedicine pharmacokinetics and tumor delivery.Computational and structural biotechnology journal · 2020Article
- On the issue of transparency and reproducibility in nanomedicine.Nature nanotechnology · 2019Article
- Establishing the effects of mesoporous silica nanoparticle properties on in vivo disposition using imaging-based pharmacokinetics.Nature communications · 2018Article
- Targeted Nanoparticle Binding to Hydroxyapatite in a High Serum Environment for Early Detection of Heart Disease.ACS applied nano materials · 2018Article
- Lipid-Coated Mesoporous Silica Nanoparticles for the Delivery of the ML336 Antiviral to Inhibit Encephalitic Alphavirus Infection.Scientific reports · 2018Article
- Mesoporous Silica Nanoparticles: A Comprehensive Review on Synthesis and Recent Advances.Pharmaceutics · 2018Review
- Understanding the Connection between Nanoparticle Uptake and Cancer Treatment Efficacy using Mathematical Modeling.Scientific reports · 2018Article
- Conjugation Chemistry-Dependent T-Cell Activation with Spherical Nucleic Acids.Journal of the American Chemical Society · 2018Article
- Silica nanoparticle stability in biological media revisited.Scientific reports · 2018Article
- Surface-Engineered Cationic Nanocrystals Stable in Biological Buffers and High Ionic Strength Solutions.Chemistry of materials : a publication of the American Chemical Society · 2017Article
- A comparison between sphere and rod nanoparticles regarding their in vivo biological behavior and pharmacokinetics.Scientific reports · 2017Article
- Differential Protein Adsorption and Cellular Uptake of Silica Nanoparticles Based on Size and Porosity.ACS applied materials & interfaces · 2016Article
- A novel approach for targeted delivery to motoneurons using cholera toxin-B modified protocells.Journal of neuroscience methods · 2016Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
The combination of nanoparticle (NP) size, charge, and surface chemistry (e.g., extent of modification with polyethylene glycol (PEG)) is accepted as a key determinant of NP/cellular interactions. However, the influence of spatial arrangement and accessibility of the charged molecules on the NP surface vis-à-vis the average surface charge (zeta (ζ) potential) is incompletely understood. Here we demonstrate that two types of mesoporous silica nanoparticles (MSNP) that are matched in terms of primary and hydrodynamic particle size, shape, pore structure, colloidal stability, and ζ potential, but differ in surface chemistry, viz. the spatial arrangement and relative exposure of surface amines, have profoundly different interactions with cells and tissues when evaluated in vitro and in vivo. While both particles are ∼50 nm in diameter, PEGylated, and positively charged (ζ = +40 mV), PEG-PEI (MSNPs modified with exposed polyamines), but not PEG-NMe3(+) (MSNP modified with distributed, obstructed amines) rapidly bind serum proteins, diverse cells types in vitro, and endothelial and white blood cells in vivo (ex ovo chick embryo model). This finding helps elucidate the relative role of surface exposure of charged molecules vs ζ potential in otherwise physicochemically matched MSNP and highlights protein corona neutrality as an important design consideration when synthesizing cationic NPs for biological applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.