ArticleJournal of cellular and molecular medicine2013
Calcium ions and osteoclastogenesis initiate the induction of bone formation by coral-derived macroporous constructs.
Article in Journal of cellular and molecular medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 53 citations in OpenAlex.
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- Parallel Chondrogenesis and Osteogenesis Tissue Morphogenesis in Muscle Tissue via Combinations of TGF-β Supergene Family Members.Cartilage · 2025Article
- A novel application perspective of the clinical-used drug verapamil on osteoporosis via targetingJournal of orthopaedic translation · 2025Article
- Sustainably cultured coral scaffold supports human bone marrow mesenchymal stromal cell osteogenesis.Regenerative therapy · 2024Article
- The induction of bone formation by 3D-printed PLGA microsphere scaffolds in a calvarial orthotopic mouse model: a pilot study.Frontiers in bioengineering and biotechnology · 2024Article
- A unique biomimetic modification endows polyetherketoneketone scaffold with osteoinductivity by activating cAMP/PKA signaling pathway.Science advances · 2022Article
- Bone Regeneration of Critical-Size Calvarial Defects in Rats Using Highly Pressed Nano-Apatite/Collagen Composites.Materials (Basel, Switzerland) · 2022Article
- Synergistic Effect of Biphasic Calcium Phosphate and Platelet-Rich Fibrin Attenuate Markers for Inflammation and Osteoclast Differentiation by SuppressingMolecules (Basel, Switzerland) · 2021Article
- Transforming Growth Factor-β3/Recombinant Human-like Collagen/Chitosan Freeze-Dried Sponge Primed With Human Periodontal Ligament Stem Cells Promotes Bone Regeneration in Calvarial Defect Rats.Frontiers in pharmacology · 2021Article
- Temporal TGF-β Supergene Family Signalling Cues Modulating Tissue Morphogenesis: Chondrogenesis within a Muscle Tissue Model?International journal of molecular sciences · 2020Article
- Trauma induced tissue survival in vitro with a muscle-biomaterial based osteogenic organoid system: a proof of concept study.BMC biotechnology · 2020Article
- Recommendations for improving accuracy of gene expression data in bone and cartilage tissue engineering.Scientific reports · 2018Article
- The material and biological characteristics of osteoinductive calcium phosphate ceramics.Regenerative biomaterials · 2018Review
- The Induction of Bone Formation: The Translation Enigma.Frontiers in bioengineering and biotechnology · 2018Review
- Functionalized Surface Geometries Induce: "Frontiers in physiology · 2017Review
- Chronic Calcium Channel Inhibitor Verapamil Antagonizes TNF-α-Mediated Inflammatory Reaction and Protects Against Inflammatory Arthritis in Mice.Inflammation · 2016Article
- Redundancy and Molecular Evolution: The Rapid Induction of Bone Formation by the Mammalian Transforming Growth Factor-β3 Isoform.Frontiers in physiology · 2016Review
- Bioactive coatings for orthopaedic implants-recent trends in development of implant coatings.International journal of molecular sciences · 2014Review
- Ectopic osteoid and bone formation by three calcium-phosphate ceramics in rats, rabbits and dogs.PloS one · 2014Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Coral-derived calcium carbonate/hydroxyapatite macroporous constructs of the genus Goniopora with limited hydrothermal conversion to hydroxyapatite (7% HA/CC) initiate the induction of bone formation. Which are the molecular signals that initiate pattern formation and the induction of bone formation? To evaluate the role of released calcium ions and osteoclastogenesis, 7% HA/CC was pre-loaded with either 500 μg of the calcium channel blocker, verapamil hydrochloride, or 240 μg of the osteoclast inhibitor, biphosphonate zoledronate, and implanted in the rectus abdominis muscle of six adult Chacma baboons Papio ursinus. Generated tissues on days 15, 60 and 90 were analysed by histomorphometry and qRT-PCR. On day 15, up-regulation of type IV collagen characterized all the implanted constructs correlating with vascular invasion. Zoledronate-treated specimens showed an important delay in tissue patterning and morphogenesis with limited bone formation. Osteoclastic inhibition yielded minimal, if any, bone formation by induction. 7% HA/CC pre-loaded with the Ca(++) channel blocker verapamil hydrochloride strongly inhibited the induction of bone formation. Down-regulation of bone morphogenetic protein-2 (BMP-2) together with up-regulation of Noggin genes correlated with limited bone formation in 7% HA/CC pre-loaded with either verapamil or zoledronate, indicating that the induction of bone formation by coral-derived macroporous constructs is via the BMPs pathway. The spontaneous induction of bone formation is initiated by a local peak of Ca(++) activating stem cell differentiation and the induction of bone formation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.