ArticleJournal of the American Chemical Society2013
Single vehicular delivery of siRNA and small molecules to control stem cell differentiation.
Article in Journal of the American Chemical Society, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 66 citations in OpenAlex.
- Advancements in Gene Delivery using Nucleic Acid Loaded Nanoparticles for Region Specific Delivery in Alzheimer's Disease.Molecular neurobiology · 2026Review
- Cell Reprogramming and Differentiation Utilizing Messenger RNA for Regenerative Medicine.Journal of developmental biology · 2023Review
- Nucleic acid drug vectors for diagnosis and treatment of brain diseases.Signal transduction and targeted therapy · 2023Review
- Nanomaterials for Biomedical Applications: Production, Characterisations, Recent Trends and Difficulties.Molecules (Basel, Switzerland) · 2021Review
- Efficient modification of PAMAM G1 dendrimer surface with β-cyclodextrin units by CuAAC: impact on the water solubility and cytotoxicity.RSC advances · 2020Article
- RNA-silencing nanoprobes for effective activation and dynamic imaging of neural stem cell differentiation.Theranostics · 2019Article
- Development of controlled drug delivery systems for bone fracture-targeted therapeutic delivery: A review.European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V · 2018Review
- CAGE: Chromatin Analogous Gene Expression.ACS synthetic biology · 2017Article
- Simultaneous delivery of hydrophobic small molecules and siRNA using Sterosomes to direct mesenchymal stem cell differentiation for bone repair.Acta biomaterialia · 2017Article
- Combination of RNA Interference and Stem Cells for Treatment of Central Nervous System Diseases.Genes · 2017Review
- Screening of efficient siRNA carriers in a library of surface-engineered dendrimers.Scientific reports · 2016Article
- Nanotechnology-Based Approaches for Guiding Neural Regeneration.Accounts of chemical research · 2016Article
- The nanomaterial toolkit for neuroengineering.Nano convergence · 2016Review
- Multidimensional nanomaterials for the control of stem cell fate.Nano convergence · 2016Review
- Induction of stem-cell-derived functional neurons by NanoScript-based gene repression.Angewandte Chemie (International ed. in English) · 2015Article
- A Cell-Permeable ATP Analogue for Kinase-Catalyzed Biotinylation.Angewandte Chemie (International ed. in English) · 2015Article
- Design, synthesis, and characterization of graphene-nanoparticle hybrid materials for bioapplications.Chemical reviews · 2015Review
- Controlling differentiation of adipose-derived stem cells using combinatorial graphene hybrid-pattern arrays.ACS nano · 2015Article
- NanoScript: a nanoparticle-based artificial transcription factor for effective gene regulation.ACS nano · 2014Article
- Guiding stem cell differentiation into oligodendrocytes using graphene-nanofiber hybrid scaffolds.Advanced materials (Deerfield Beach, Fla.) · 2014Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Achieving a controlled and reproducible means to direct stem cell differentiation is the single most critical concern scientists have been trying to address since the discovery of stem cells. In this regard, the use of small molecules and RNA interference offers unique advantages by targeting different cellular mechanisms. Our cyclodextrin-modified dendritic polyamine construct (termed DexAM) combines the unique properties of two distinct chemical moieties in a single delivery vehicle. DexAM is a single vehicle that not only solubilizes hydrophobic small molecules in physiological solutions but also forms complexes with siRNA molecules, making it an attractive delivery system for controlling stem cell differentiation. Herein, we report the synthesis and application of DexAM to simultaneously deliver hydrophobic small molecules and siRNA into neural stem cells to significantly enhance their neuronal differentiation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.