ArticleBioMed research international2013
Osteogenic matrix cell sheet transplantation enhances early tendon graft to bone tunnel healing in rabbits.
Article in BioMed research international, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 30 citations in OpenAlex.
- MgO-enhanced β-TCP promotes osteogenesis in both in vitro and in vivo rat models.Scientific reports · 2024Article
- Effects of Induction Culture on Osteogenesis of Scaffold-Free Engineered Tissue for Bone Regeneration Applications.Tissue engineering and regenerative medicine · 2022Article
- Silicate/zinc-substituted strontium apatite coating improves the osteoinductive properties of β-tricalcium phosphate bone graft substitute.BMC musculoskeletal disorders · 2021Article
- Frozen-thawed gelatin-induced osteogenic cell sheets of canine adipose-derived mesenchymal stromal cells improved fracture healing in canine model.Journal of veterinary science · 2019Article
- Silicate-substituted strontium apatite nano coating improves osteogenesis around artificial ligament.BMC musculoskeletal disorders · 2019Article
- Osteogenesis of osteogenic matrix cell sheets preserved in culture medium in a rat model.Cell transplantation · 2018Article
- Different Bone Healing Effects of Undifferentiated and Osteogenic Differentiated Mesenchymal Stromal Cell Sheets in Canine Radial Fracture Model.Tissue engineering and regenerative medicine · 2018Article
- Implantation of Bone Marrow Stromal Cell Sheets Derived from Old Donors Supports Bone Tissue Formation.Tissue engineering and regenerative medicine · 2018Article
- Boosting tendon repair: interplay of cells, growth factors and scaffold-free and gel-based carriers.Journal of experimental orthopaedics · 2018Review
- Bone regeneration with osteogenic matrix cell sheet and tricalcium phosphate: An experimental study in sheep.World journal of orthopedics · 2017Article
- Modifying oxygen tension affects bone marrow stromal cell osteogenesis for regenerative medicine.World journal of stem cells · 2017Article
- Effect of Gelatin on Osteogenic Cell Sheet Formation Using Canine Adipose-Derived Mesenchymal Stem Cells.Cell transplantation · 2017Article
- Novel use of cranial epidural space in rabbits as an animal model to investigate bone volume augmentation potential of different bone graft substitutes.Head & face medicine · 2016Article
- Culturing bone marrow cells with dexamethasone and ascorbic acid improves osteogenic cell sheet structure.Bone & joint research · 2016Article
- Utility of tricalcium phosphate and osteogenic matrix cell sheet constructs for bone defect reconstruction.World journal of stem cells · 2015Article
- Effects of Artificial Ligaments with Different Porous Structures on the Migration of BMSCs.Stem cells international · 2015Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective of this study was to determine whether osteogenic matrix cell sheets (OMCS) could induce bone formation around grafted tendons, thereby enhancing early stage tendon to bone tunnel healing in skeletally mature male Japanese white rabbits. First, the osteogenic potential of rabbit OMCS was evaluated. Then, the OMCS were transplanted into the interface between the grafted tendon and the bone tunnel created at the tibia. Histological assessments and biomechanical tensile testing were performed after 3 weeks. The rabbit OMCS showed high alkaline phosphatase (ALP) activity, positive staining of ALP, and osteogenic potential when transplanted subcutaneously with beta tricalcium phosphate disks. Newly formed bony walls and positive collagen type I staining were seen around the grafted tendon with OMCS transplantation, whereas such bony walls were thinner or less frequent without OMCS transplantation. Micro-computed tomography images showed significantly higher bone volume in the OMCS transplantation group. The pullout strength was significantly higher with OMCS (0.74 ± 0.23 N/mm(2)) than without OMCS (0.58 ± 0.15 N/mm(2)). These results show that OMCS enhance early tendon to bone tunnel healing. This method can be applied to cases requiring early tendon to bone tunnel healing after ligament reconstruction surgery.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.