ArticleBioMed research international2013
Allergy or tolerance: reduced inflammatory cytokine response and concomitant IL-10 production of lymphocytes and monocytes in symptom-free titanium dental implant patients.
Article in BioMed research international, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 39 citations in OpenAlex.
- Risk Factors Contributing to Symptomatic Miniplate Removal following Orthognathic Surgery: Systematic Review and Meta-Analysis.Journal of clinical medicine · 2024Review
- Internal surface modification of additively manufactured macroporous TiAl6V4 biomimetic implants via a calciothermic reaction-based process and osteogenic in vivo responses.Journal of biomedical materials research. Part B, Applied biomaterials · 2024Article
- Titanium Allergy Caused by Dental Implants: A Systematic Literature Review and Case Report.Materials (Basel, Switzerland) · 2021Review
- Cross-sectional evaluation of clinical and immunological parameters at partially microgrooved vs machined abutments in humans.International journal of implant dentistry · 2021Article
- Usefulness of lymphocyte transformation test and in vitro cytokine release in differentiating between independent and cross-reacting nickel/palladium allergy.Immunity, inflammation and disease · 2020Article
- Actovegin® reduces PMA-induced inflammation on human cells.European journal of applied physiology · 2020Article
- Exploring the Incidence, Implications, and Relevance of Metal Allergy to Orthopaedic Surgeons.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2019Article
- Blood cytokine pattern and clinical outcome in knee arthroplasty patients: comparative analysis 5 years after standard versus "hypoallergenic" surface coated prosthesis implantation.Acta orthopaedica · 2018Article
- [Compatibility and allergies of osteosynthesis materials].Der Unfallchirurg · 2017Review
- Polymorphisms of Il-10 (-1082) and RANKL (-438) Genes and the Failure of Dental Implants.International journal of dentistry · 2017Article
- [Synovial biomarkers for differential diagnosis of painful arthroplasty].Der Orthopade · 2015Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hypersensitivity reactions to titanium (Ti) are very rare. Thus, we assessed the proinflammatory response and also potential tolerance favoring in vitro reactivity of human blood lymphocytes and monocytes (PBMC) to Ti in healthy individuals (14 without, 6 with complication-free dental Ti implants). The proliferation index (SI) in lymphocyte transformation test (LTT) and production of cytokines linked to innate immune response (IL-1 β , IL-6, and TNF α ) or immune regulation (IL-10) were assessed in response to TiO2 particles or Ti discs. In both groups, the Ti-LTT reactivity was not enhanced (e.g., SI < 3). The control antigen tetanus toxoid (TT) gave adequate reactivity (median SI individuals without/with implant: 20.6 ± 5.97/19.58 ± 2.99). Individuals without implant showed higher cytokine response to Ti materials than individuals with symptom-free implants; for example, TiO2 rutile particle induced increase of IL-1 β 70.27-fold/8.49-fold versus control medium culture. PBMC of 5 of the 6 individuals with complication-free Ti implants showed an ex vivo ongoing production of IL-10 (mean 4.18 ± 2.98 pg/mL)-but none of the 14 controls showed such IL-10 production. Thus in vitro IL-1 β -, IL-6-, and TNF- α production reflects "normal" unspecific immune response to Ti. This might be reduced by production of tolerogenic IL-10 in individuals with symptom-free Ti dental implants.
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