ArticleThe Journal of infectious diseases2014
Molecular characterization of a novel botulinum neurotoxin type H gene.
Article in The Journal of infectious diseases, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 137 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
137 citing papers in PubMed, 2 syntheses or guidelines pooled it, 278 citations in OpenAlex.
- Botulism in the 21st Century: A Scoping Review.The Brown journal of hospital medicine · 2023Pooled it
- Guideline
- Advances in Clostridial Neurotoxins: Passage of the Intestinal Barrier and Targeting of Specific Neuronal Cells.Toxins · 2026Review
- Development and Humanization of a Camelid-Derived Neutralizing Nanobody Targeting Botulinum Neurotoxin Type A.International journal of nanomedicine · 2026Article
- Antibody-Integrated Solid-to-Gel Microfilm for Protection Against Botulinum Neurotoxin Type A.Gels (Basel, Switzerland) · 2025Article
- Article
- Botulinum Neurotoxins as Two-Faced Janus Proteins.Biomedicines · 2025Review
- Elevated incidence of infant botulism in a 17-county area of the Mid-Atlantic region in the United States, 2000-2019, including association with soil types.Applied and environmental microbiology · 2024Article
- Selection of Candidate Monoclonal Antibodies for Therapy of Botulinum Toxin Type A Intoxications.Toxins · 2024Article
- Embracing the Versatility of Botulinum Neurotoxins in Conventional and New Therapeutic Applications.Toxins · 2024Review
- Biosafety, biosecurity, and bioethics.Monash bioethics review · 2024Review
- A DARPin promotes faster onset of botulinum neurotoxin A1 action.Nature communications · 2023Article
- Pathogenicity and virulence ofVirulence · 2023Review
- Openness in Scientific Research: A Historical and Philosophical Perspective.Journal of open access to law · 2023Article
- Review
- Review
- Botulism in Cattle: A Case Report of an Outbreak in Sardinia (Italy).Animals : an open access journal from MDPI · 2023Article
- Surge in iatrogenic botulism cases in Europe: Threat perceptions and salient countering measures.New microbes and new infections · 2023Article
- Crystal structures of OrfX1, OrfX2 and the OrfX1-OrfX3 complex from the orfX gene cluster of botulinum neurotoxin E1.FEBS letters · 2023Article
- Article
77 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We sequenced the 2 botulinum toxin gene clusters of Clostridium botulinum strain IBCA10-7060 type Bh. The sequence of bont/H differed substantially from the sequences of the 7 known bont genes for toxin types A-G. The 5' one-third terminus of bont/H that codes for the botulinum toxin light chain differed markedly from the light chain coding sequences of toxin types A-G. The 3' two-thirds terminus of bont/H that codes for the botulinum toxin heavy chain contained a novel Hn translocation domain coding sequence and a nonneutralizing type A-like Hc binding domain coding sequence. bont/H was part of an orfX toxin gene cluster that was located at a unique chromosomal site distant from those used by other botulinum toxin gene clusters. The bont/B sequence was similar to that of subtype bont/B2 and was located within its ha toxin gene cluster at the oppA/brnQ site. Our findings further establish that C. botulinum IBCA10-7060 produces novel BoNT/H.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.