Evidence map›Paper›PMID 24106264›Full record

ReviewThe Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry2014

IA channels: diverse regulatory mechanisms.

Yarimar Carrasquillo, Jeanne M Nerbonne

Open access · greenAbstract readReview
In one paragraph

Review in The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 47 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Variation of Two S3b Residues in KFrontiers in pharmacology · 2021
    Article
  14. Article
  15. Review
  16. Review
  17. Castration Induces Down-Regulation of A-Type KInternational journal of molecular sciences · 2019
    Article
  18. Article
  19. Modulation of KPflugers Archiv : European journal of physiology · 2019
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Yarimar Carrasquillo1Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO, USA.
Jeanne M Nerbonne
Washington University in St. Louis · US

Funding

ION CHANNELS IN THE FUNCTIONING OF CORTICAL NEURONSR01NS030676 · NINDS · WASHINGTON UNIVERSITY · PI NERBONNE, JEANNE M. · 1993 to 2005
$1.5M
Molecular Dissection of Neuronal K+ Channel FunctionR01NS041417 · NINDS · WASHINGTON UNIVERSITY · PI NERBONNE, JEANNE M. · 2002 to 2005
$1.0M
Novel role for SCN1b as a modulator of Kv4.2 channels and neuronal excitabilityF32NS065581 · NINDS · WASHINGTON UNIVERSITY · PI CARRASQUILLO-GARCIA, YARIMAR · 2009 to 2010
$106k
NINDS NIH HHS F32 NS-065581NINDS NIH HHS F32 NS065581NINDS NIH HHS R01 NS030676NINDS NIH HHS R01 NS-03676NINDS NIH HHS R01 NS041417
6 · The paper itself

Abstract

In many peripheral and central neurons, A-type K(+) currents, IA, have been identified and shown to be key determinants in shaping action potential waveforms and repetitive firing properties, as well as in the regulation of synaptic transmission and synaptic plasticity. The functional properties and physiological roles of native neuronal IA, however, have been shown to be quite diverse in different types of neurons. Accumulating evidence suggests that this functional diversity is generated by multiple mechanisms, including the expression and subcellular distributions of IA channels encoded by different voltage-gated K(+) (Kv) channel pore-forming (α) subunits, interactions of Kv α subunits with cytosolic and/or transmembrane accessory subunits and regulatory proteins and post-translational modifications of channel subunits. Several recent reports further suggest that local protein translation in the dendrites of neurons and interactions between IA channels with other types of voltage-gated ion channels further expands the functional diversity of native neuronal IA channels. Here, we review the diverse molecular mechanisms that have been shown or proposed to underlie the functional diversity of native neuronal IA channels.

Indexed as

AnimalsNeuronsPotassium Channels, Voltage-GatedPotassium Channels, Voltage-GatedKv12 channelsKv1 channelsKv4 channelsKv channel accessory subunitsposttranslational regulation of Kv channels

Identifiers

PMID24106264
PMCPMC10158498
OpenAlexW1980187628

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.