ArticleBlood2013
Coordinated and unique functions of the E-selectin ligand ESL-1 during inflammatory and hematopoietic recruitment in mice.
Article in Blood, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Neutrophil Mechanosignaling Promotes Integrin Engagement With Endothelial Cells and Motility Within Inflamed Vessels.Frontiers in immunology · 2018Trial
- The Role of Glycans in Human Immunity-A Sweet Code.Molecules (Basel, Switzerland) · 2025Review
- Emerging insights into epigenetics and hematopoietic stem cell trafficking in age-related hematological malignancies.Stem cell research & therapy · 2024Review
- Oxidative Stress Induces E-Selectin Expression through Repression of Endothelial Transcription Factor ERG.Journal of immunology (Baltimore, Md. : 1950) · 2023Article
- Role of Stromal Cell-Derived Factor-1 in Endothelial Progenitor Cell-Mediated Vascular Repair and Regeneration.Tissue engineering and regenerative medicine · 2021Review
- Acute Myeloid Leukemia Chemo-Resistance Is Mediated by E-selectin Receptor CD162 in Bone Marrow Niches.Frontiers in cell and developmental biology · 2020Article
- The physical microenvironment of hematopoietic stem cells and its emerging roles in engineering applications.Stem cell research & therapy · 2019Review
- Exercise and Cardiovascular Progenitor Cells.Comprehensive Physiology · 2019Review
- Hematopoietic stem cells under pressure.Current opinion in hematology · 2017Review
- Antibody blockade of CLEC12A delays EAE onset and attenuates disease severity by impairing myeloid cell CNS infiltration and restoring positive immunity.Scientific reports · 2017Article
- SDF-1α-induced dual pairs of E-selectin/ligand mediate endothelial progenitor cell homing to critical ischemia.Scientific reports · 2016Article
- p38γ and p38δ reprogram liver metabolism by modulating neutrophil infiltration.The EMBO journal · 2016Article
- Haematopoietic ESL-1 enables stem cell proliferation in the bone marrow by limiting TGFβ availability.Nature communications · 2016Article
- Intracellular signalling during neutrophil recruitment.Cardiovascular research · 2015Review
- Cytoskeletal regulation of CD44 membrane organization and interactions with E-selectin.The Journal of biological chemistry · 2014Article
- E-selectin ligand-1 controls circulating prostate cancer cell rolling/adhesion and metastasis.Oncotarget · 2014Article
- Hematopoietic stem cell niche maintenance during homeostasis and regeneration.Nature medicine · 2014Review
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9 authors.
Funding
Abstract
Beyond its well-established roles in mediating leukocyte rolling, E-selectin is emerging as a multifunctional receptor capable of inducing integrin activation in neutrophils, and of regulating various biological processes in hematopoietic precursors. Although these effects suggest important homeostatic contributions of this selectin in the immune and hematologic systems, the ligands responsible for transducing these effects in different leukocyte lineages are not well defined. We have characterized mice deficient in E-selectin ligand-1 (ESL-1), or in both P-selectin glycoprotein-1 (PSGL-1) and ESL-1, to explore and compare the contributions of these glycoproteins in immune and hematopoietic cell trafficking. In the steady state, ESL-1 deficiency resulted in a moderate myeloid expansion that became more prominent when both glycoproteins were eliminated. During inflammation, PSGL-1 dominated E-selectin binding, rolling, integrin activation, and extravasation of mature neutrophils, but only the combined deficiency in PSGL-1 and ESL-1 completely abrogated leukocyte recruitment. Surprisingly, we find that the levels of ESL-1 were strongly elevated in hematopoietic progenitor cells. These elevations correlated with a prominent function of ESL-1 for E-selectin binding and for migration of hematopoietic progenitor cells into the bone marrow. Our results uncover dominant roles for ESL-1 in the immature compartment, and a functional shift toward PSGL-1 dependence in mature neutrophils.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.