ArticleBriefings in functional genomics2013
From a gene-centric to whole-proteome view of differentiation of T helper cell subsets.
Article in Briefings in functional genomics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- A primary human T-cell spectral library to facilitate large scale quantitative T-cell proteomics.Scientific data · 2020Article
- Methrotexate Treatment Inmunomodulates Abnormal Cytokine Expression by T CD4 Lymphocytes Present in DMARD-Naïve Rheumatoid Arthritis Patients.International journal of molecular sciences · 2020Article
- Modulation of Allergic Sensitization and Allergic Inflammation byFrontiers in immunology · 2020Article
- seq-ImmuCC: Cell-Centric View of Tissue Transcriptome Measuring Cellular Compositions of Immune Microenvironment From Mouse RNA-Seq Data.Frontiers in immunology · 2018Article
- A Combined Omics Approach to Generate the Surface Atlas of Human Naive CD4+ T Cells during Early T-Cell Receptor Activation.Molecular & cellular proteomics : MCP · 2015Article
- Cell-selective labelling of proteomes in Drosophila melanogaster.Nature communications · 2015Article
Corrections and comments
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Authors and funding
3 authors.
Funding
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Abstract
Proper differentiation of naïve T helper cells into functionally distinct subsets is of critical importance to human health. Consequently, the process is tightly controlled by a complex intracellular signalling network. To dissect the regulatory principles of this network, immunologists have early on embraced system-wide transcriptomics tools, leading to identification of large panels of potential regulatory factors. In contrast, the use of proteomics approaches in T helper cell research has been notably rare, and to this date relatively few high-throughput datasets have been reported. Here, we discuss the importance of such research and envision the possibilities afforded by mass spectrometry-based proteomics in the near future.
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