ReviewBioEssays : news and reviews in molecular, cellular and developmental biology2013
How do taste cells lacking synapses mediate neurotransmission? CALHM1, a voltage-gated ATP channel.
Review in BioEssays : news and reviews in molecular, cellular and developmental biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 64 citations in OpenAlex.
- Article
- Interkingdom Detection of Bacterial Quorum-Sensing Molecules by Mammalian Taste Receptors.Microorganisms · 2023Review
- Taste arbor structural variability analyzed across taste regions.The Journal of comparative neurology · 2023Article
- Taste Receptor Signaling.Handbook of experimental pharmacology · 2022Article
- Mechanisms for the Sour Taste.Handbook of experimental pharmacology · 2022Article
- Human CALHM5: Insight in large pore lipid gating ATP channel and associated neurological pathologies.Molecular and cellular biochemistry · 2021Review
- In vivo Calcium Imaging of Mouse Geniculate Ganglion Neuron Responses to Taste Stimuli.Journal of visualized experiments : JoVE · 2021Article
- Bitter taste receptor agonists regulate epithelial two-pore potassium channels via cAMP signaling.Respiratory research · 2021Article
- Taste transduction and channel synapses in taste buds.Pflugers Archiv : European journal of physiology · 2021Review
- Cryo-EM structures of calcium homeostasis modulator channels in diverse oligomeric assemblies.Science advances · 2020Article
- Article
- Structures of CALHM channels revealed.Nature structural & molecular biology · 2020Article
- CALHM1/CALHM3 channel is intrinsically sorted to the basolateral membrane of epithelial cells including taste cells.Scientific reports · 2019Article
- Taste Receptors: New Players in Sperm Biology.International journal of molecular sciences · 2019Review
- Spilanthol Enhances Sensitivity to Sodium in Mouse Taste Bud Cells.Chemical senses · 2019Article
- The role of bitter and sweet taste receptors in upper airway innate immunity: Recent advances and future directions.World journal of otorhinolaryngology - head and neck surgery · 2018Review
- Chemical synapses without synaptic vesicles: Purinergic neurotransmission through a CALHM1 channel-mitochondrial signaling complex.Science signaling · 2018Article
- ATP Release Channels.International journal of molecular sciences · 2018Review
- TRPM4 and TRPM5 are both required for normal signaling in taste receptor cells.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Role of Taste Receptors as Sentinels of Innate Immunity in the Upper Airway.Journal of pathogens · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
CALHM1 was recently demonstrated to be a voltage-gated ATP-permeable ion channel and to serve as a bona fide conduit for ATP release from sweet-, umami-, and bitter-sensing type II taste cells. Calhm1 is expressed in taste buds exclusively in type II cells and its product has structural and functional similarities with connexins and pannexins, two families of channel protein candidates for ATP release by type II cells. Calhm1 knockout in mice leads to loss of perception of sweet, umami, and bitter compounds and to impaired gustatory nerve responses to these tastants. These new studies validate the concept of ATP as the primary neurotransmitter from type II cells to gustatory neurons. Furthermore, they identify voltage-gated ATP release through CALHM1 as an essential molecular mechanism of ATP release in taste buds. We discuss these new findings, as well as unresolved issues in peripheral taste signaling that we hope will stimulate future research.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.