Evidence map›Paper›PMID 24105719›Full record

ReviewMolecular reproduction and development2013

Defining the neighborhoods that escort the oocyte through its early life events and into a functional follicle.

Joan S Jorgensen

Open access · bronzeAbstract readReview
In one paragraph

Review in Molecular reproduction and development, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 33 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Joan S JorgensenDepartment of Comparative Biosciences, University of Wisconsin, Madison, Wisconsin.
University of Wisconsin–Madison · US

Funding

IRXB Factors Direct Follicle MaturationR01HD075079 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI JORGENSEN, JOAN S · 2013 to 2017
$1.6M
NICHD NIH HHS R01 HD075079NICHD NIH HHS R01HD075079
6 · The paper itself

Abstract

The ovary functions to chaperone the most precious cargo for female individuals, the oocyte, thereby allowing the passage of genetic material to subsequent generations. Within the ovary, single oocytes are surrounded by a legion of granulosa cells inside each follicle. These two cell types depend upon one another to support follicle formation and oocyte survival. The infrastructure and events that work together to ultimately form these functional follicles within the ovary are unprecedented, given that the oocyte originates as a cell like all other neighboring cells within the embryo prior to gastrulation. This review discusses the journey of the germ cell in the context of the developing female mouse embryo, with a focus on specific signaling events and cell-cell interactions that escort the primordial germ cell as it is specified into the germ cell fate, migrates through the hindgut into the gonad, differentiates into an oocyte, and culminates upon formation of the primordial and then primary follicle.

Indexed as

AnimalsCdh1 ProteinsCell CommunicationCell DifferentiationCell MovementFemaleGranulosa CellsMiceOocytesOvarian FollicleSignal TransductionCdh1 ProteinsFzr1 protein, mouse

Identifiers

PMID24105719
PMCPMC3980676
OpenAlexW2101037544

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.