ArticleEndocrinology2013
Inhibition of hippocampal aromatization impairs spatial memory performance in a male songbird.
Article in Endocrinology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.
- What do zebra finches learn besides singing? Systematic mapping of the literature and presentation of an efficient associative learning test.Animal cognition · 2023Pooled it
- The Lysine Acetyltransferase PCAF Functionally Interacts with Estrogen Receptor Alpha in the Hippocampus of Gonadally Intact Male-But Not Female-Rats to Enhance Short-Term Memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Spatial and temporal specificity of neuroestradiol provision in the songbird.Journal of neuroendocrinology · 2023Review
- Letrozole treatment alters hippocampal gene expression in common marmosets (Callithrix jacchus).Hormones and behavior · 2023Article
- Sex-specific regulation of inhibition and network activity by local aromatase in the mouse hippocampus.Nature communications · 2022Article
- Brain-derived estrogen and neural function.Neuroscience and biobehavioral reviews · 2022Review
- Neuron-Derived Estrogen-A Key Neuromodulator in Synaptic Function and Memory.International journal of molecular sciences · 2021Review
- Hippocampal Aromatase Knockdown Aggravates Ovariectomy-Induced Spatial Memory Impairment, Aβ Accumulation and Neural Plasticity Deficiency in Adult Female Mice.Neurochemical research · 2021Article
- Oestradiol as a neuromodulator of learning and memory.Nature reviews. Neuroscience · 2020Review
- Neuroestrogen synthesis modifies neural representations of learned song without altering vocal imitation in developing songbirds.Scientific reports · 2020Article
- Rapid Estrogenic and Androgenic Neurosteroids Effects in the Induction of Long-Term Synaptic Changes: Implication for Early Memory Formation.Frontiers in neuroscience · 2020Review
- Estrogen as a Neuroprotectant in Both Sexes: Stories From the Bird Brain.Frontiers in neurology · 2020Review
- Non-reproductive Functions of Aromatase in the Central Nervous System Under Physiological and Pathological Conditions.Cellular and molecular neurobiology · 2019Review
- Activation of androgen receptors protects intact male mice from memory impairments caused by aromatase inhibition.Hormones and behavior · 2019Article
- Preparing to migrate: expression of androgen signaling molecules and insulin-like growth factor-1 in skeletal muscles of Gambel's white-crowned sparrows.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2019Article
- Estrogenic regulation of memory consolidation: A look beyond the hippocampus, ovaries, and females.Physiology & behavior · 2018Review
- Triclosan Impairs Hippocampal Synaptic Plasticity and Spatial Memory in Male Rats.Frontiers in molecular neuroscience · 2018Article
- Differential activation of endocrine-immune networks by arthritis challenge: Insights from colony-specific responses.Scientific reports · 2017Article
- Hippocampal Aromatization Modulates Spatial Memory and Characteristics of the Synaptic Membrane in the Male Zebra Finch.Endocrinology · 2017Article
- Actions of Steroids: New Neurotransmitters.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Recent studies have revealed the presence and regulation of aromatase at the vertebrate synapse, and identified a critical role played by presynaptic estradiol synthesis in the electrophysiological response to auditory and other social cues. However, if and how synaptic aromatization affects behavior remains to be directly tested. We have exploited 3 characteristics of the zebra finch hippocampus (HP) to test the role of synaptocrine estradiol provision on spatial memory function. Although the zebra finch HP contains abundant aromatase transcripts and enzyme activity, immunocytochemical studies reveal widespread pre- and postsynaptic, but sparse to undetectable somal, localization of this enzyme. Further, the superficial location of the avian HP makes possible the more exclusive manipulation of its neurochemical characteristics without perturbation of the neuropil and the resultant induction of astroglial aromatase. Last, as in other vertebrates, the HP is critical for spatial memory performance in this species. Here we report that local inhibition of hippocampal aromatization impairs spatial memory performance in an ecologically valid food-finding task. Local aromatase inhibition also resulted in lower levels of estradiol in the HP, but not in adjacent brain areas, and was achieved without the induction of astroglial aromatase. The observed decrement in acquisition and subsequent memory performance as a consequence of lowered aromatization was similar to that achieved by lesioning this locus. Thus, hippocampal aromatization, much of which is achieved at the synapse in this species, is critical for spatial memory performance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.