ArticleRadiation and environmental biophysics2014
Predicted cancer risks induced by computed tomography examinations during childhood, by a quantitative risk assessment approach.
Article in Radiation and environmental biophysics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Centers for Disease Control and Prevention Guideline on the Diagnosis and Management of Mild Traumatic Brain Injury Among Children.JAMA pediatrics · 2018Guideline
- Clinical Determinants of Dose-Length Product in Pediatric Brain CT: Implications for Age-Specific Imaging Protocols.Journal of imaging · 2026Article
- PERC-Peds rule for bedside exclusion of pulmonary embolism without radiation in children in the USA (BEEPER): a multicentre, prospective, observational, diagnostic accuracy study.The Lancet. Respiratory medicine · 2026Observational
- Establishing Local Diagnostic Reference Levels (DRLs) for Adult Computed Tomography in Emirates Health Services Hospitals: A Multicenter Dose Survey.Diagnostics (Basel, Switzerland) · 2026Article
- Ultrasound Diagnosis of Acute Appendicitis in Pediatrics: A Community Hospital Network Experience.Cureus · 2025Article
- Primary Mold-Active Antifungal Prophylaxis Decreases the Need for Chest Computed Tomography Scans in Patients with Acute Lymphoblastic Leukemia.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2024Article
- The impact of environmental factors and contaminants on thyroid function and disease from fetal to adult life: current evidence and future directions.Frontiers in endocrinology · 2024Review
- Venous 3D Phase Contrast Magnetic Resonance Angiography Increases Diagnostic Certainty in Children with Ventriculoperitoneal Shunt and Suspected Shunt Failure.Clinical neuroradiology · 2023Article
- Application of intentional facial nerve stimulation during cochlear implantation as an electrophysiological tool to estimate the intracochlear electrode position.Scientific reports · 2022Article
- Guidelines for reasonable and appropriate care in the emergency department (GRACE): Recurrent, low-risk chest pain in the emergency department.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2021Article
- Mixed reality models based on low-dose computed tomography technology in nephron-sparing surgery are better than models based on normal-dose computed tomography.Quantitative imaging in medicine and surgery · 2021Article
- Risk trade-off analysis of returning home and radiation exposure after a nuclear disaster using a happy life expectancy indicator.Journal of radiation research · 2021Article
- Local Diagnostic Reference Levels for Paediatric Head CT Procedures.Acta medica Lituanic · 2021Article
- Deep learning-based attenuation correction in the absence of structural information for whole-body positron emission tomography imaging.Physics in medicine and biology · 2020Article
- A Scalable Database of Organ Doses for Common Diagnostic Fluoroscopy Procedures of Children: Procedures of Historical Practice for Use in Radiation Epidemiology Studies.Radiation research · 2019Article
- Imaging in craniosynostosis: when and what?Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2019Review
- Zero Fluoroscopy During Ablation of Right-Sided Supraventricular Tachycardia Substrates in a Pediatric Population - Initial Experience in Taiwan.Acta Cardiologica Sinica · 2019Article
- Risk of Brain Tumor Induction from Pediatric Head CT Procedures: A Systematic Literature Review.Brain tumor research and treatment · 2018Review
- Importance of risk comparison for individual and societal decision-making after the Fukushima disaster.Journal of radiation research · 2018Review
- Long-term changes in computed tomography and ultrasound utilization in a pediatric emergency department.Clinical and experimental emergency medicine · 2018Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The potential adverse effects associated with exposure to ionizing radiation from computed tomography (CT) in pediatrics must be characterized in relation to their expected clinical benefits. Additional epidemiological data are, however, still awaited for providing a lifelong overview of potential cancer risks. This paper gives predictions of potential lifetime risks of cancer incidence that would be induced by CT examinations during childhood in French routine practices in pediatrics. Organ doses were estimated from standard radiological protocols in 15 hospitals. Excess risks of leukemia, brain/central nervous system, breast and thyroid cancers were predicted from dose-response models estimated in the Japanese atomic bomb survivors' dataset and studies of medical exposures. Uncertainty in predictions was quantified using Monte Carlo simulations. This approach predicts that 100,000 skull/brain scans in 5-year-old children would result in eight (90 % uncertainty interval (UI) 1-55) brain/CNS cancers and four (90 % UI 1-14) cases of leukemia and that 100,000 chest scans would lead to 31 (90 % UI 9-101) thyroid cancers, 55 (90 % UI 20-158) breast cancers, and one (90 % UI <0.1-4) leukemia case (all in excess of risks without exposure). Compared to background risks, radiation-induced risks would be low for individuals throughout life, but relative risks would be highest in the first decades of life. Heterogeneity in the radiological protocols across the hospitals implies that 5-10 % of CT examinations would be related to risks 1.4-3.6 times higher than those for the median doses. Overall excess relative risks in exposed populations would be 1-10 % depending on the site of cancer and the duration of follow-up. The results emphasize the potential risks of cancer specifically from standard CT examinations in pediatrics and underline the necessity of optimization of radiological protocols.
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