Evidence map›Paper›PMID 24105342›Full record

ReviewNature reviews. Neuroscience2013

Molecular logic of neocortical projection neuron specification, development and diversity.

L C Greig, M B Woodworth, M J Galazo, H Padmanabhan, J D Macklis

Abstract readReview
In one paragraph

Review in Nature reviews. Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 527 papers.

0numbers the graph read from it
0cells of the map it votes in
527citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

527 citing papers in PubMed.

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  10. Cross-Modal Denoising and Integration of Spatial Multi-Omics Data with CANDIES.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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  13. CRL4EMBO reports · 2026
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467 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

L C Greig *
M B Woodworth
M J Galazo
H Padmanabhan
J D Macklis

Funding

Medical Scientist Training ProgramT32GM007753 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WALENSKY, LOREN DAVID · 1985 to 2021
$50.0M
Molecular Controls over Neurogenesis, Subtype Development, and Diversity of Cortical Output Projection NeuronsR01NS045523 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI MACKLIS, JEFFREY D · 2002 to 2020
$5.4M
Neocortical Precursor Transplant for Circuitry RepairR37NS041590 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI MACKLIS, JEFFREY D · 2004 to 2010
$2.9M
Molecular Mechanisms of CTIP2 Function in Corticospinal Motor Neuron DevelopmentR01NS075672 · NINDS · HARVARD UNIVERSITY · PI MACKLIS, JEFFREY D · 2012 to 2016
$1.8M
Cortico-Spinal Repopulation from Precursors for RepairR01NS049553 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI MACKLIS, JEFFREY D · 2004 to 2007
$1.6M
NEOCORTICAL PRECURSOR TRANSPLANTS FOR CIRCUITRY REPAIRR01NS041590 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI MACKLIS, JEFFREY D · 2000 to 2003
$1.5M
Ctip2 Function in Corticospinal Motor Neuron DevelopmentF31NS064730 · NINDS · HARVARD MEDICAL SCHOOL · PI WOODWORTH, MOLLIE BURGOON · 2010 to 2012
$86k
Ctip1 Function in Neocortical Projection Neuron Subtype Specification and ArealizF31NS080343 · NINDS · HARVARD MEDICAL SCHOOL · PI CUSTO GREIG, LUCIANO F · 2012 to 2013
$72k
NIGMS NIH HHS T32 GM007753NINDS NIH HHS F31 NS064730NINDS NIH HHS F31 NS080343NINDS NIH HHS NS041590NINDS NIH HHS NS045523NINDS NIH HHS NS049553NINDS NIH HHS NS064730NINDS NIH HHS NS075672NINDS NIH HHS NS080343NINDS NIH HHS R01 NS045523NINDS NIH HHS R01 NS049553NINDS NIH HHS R01 NS075672NINDS NIH HHS R37 NS041590
6 · The paper itself

Abstract

The sophisticated circuitry of the neocortex is assembled from a diverse repertoire of neuronal subtypes generated during development under precise molecular regulation. In recent years, several key controls over the specification and differentiation of neocortical projection neurons have been identified. This work provides substantial insight into the 'molecular logic' underlying cortical development and increasingly supports a model in which individual progenitor-stage and postmitotic regulators are embedded within highly interconnected networks that gate sequential developmental decisions. Here, we provide an integrative account of the molecular controls that direct the progressive development and delineation of subtype and area identity of neocortical projection neurons.

Indexed as

Biological EvolutionGene Expression Regulation, DevelopmentalHumansMitosisNeocortexNerve NetNeural PathwaysNeural Stem CellsNeurons

Identifiers

PMID24105342
PMCPMC3876965

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.