ArticleDiabetologia2014
Association between alcohol consumption and plasma fetuin-A and its contribution to incident type 2 diabetes in women.
Article in Diabetologia, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03173586 (Association Between Sugar Sweetened Beverage Intake and Biomarkers of Cardiometabolic Risk in US Women), which is not on this map. Cited by 9 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Association Between Sugar Sweetened Beverage Intake and Biomarkers of Cardiometabolic Risk in US Women
Who cites it
9 citing papers in PubMed, 28 citations in OpenAlex.
- Fetuin-A Can Assess the Severity of Alcohol-Related Liver Disease.Medicina (Kaunas, Lithuania) · 2025Article
- You are What You Drink? How Associations Between Profiles of Beverage Consumption and Type 2 Diabetes Risk are Mediated by Biomarker Networks.The American journal of clinical nutrition · 2023Article
- Liver-adipose tissue crosstalk in alcohol-associated liver disease: The role of mTOR.Liver research (Beijing, China) · 2022Article
- Association of Habitual Alcohol Consumption With Long-term Risk of Type 2 Diabetes Among Women With a History of Gestational Diabetes.JAMA network open · 2021Article
- Alcohol-induced impaired insulin secretion in a Japanese population: 5-year follow up in the Gifu Diabetes Study.Journal of diabetes investigation · 2020Article
- Cross-sectional association between sugar-sweetened beverage intake and cardiometabolic biomarkers in US women.The British journal of nutrition · 2018Article
- Association between Healthy Eating Index-2010 and Fetuin-A Levels in Patients with Type 2 Diabetes: a Case-Control Study.Clinical nutrition research · 2017Article
- Association of alcohol consumption and components of metabolic syndrome among people in rural China.Nutrition & metabolism · 2015Article
- Effect of moderate alcohol consumption on fetuin-A levels in men and women: post-hoc analyses of three open-label randomized crossover trials.Diabetology & metabolic syndrome · 2014Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
aims/hypothesisThe benefits of moderate alcohol consumption for type 2 diabetes have been postulated to involve a mechanism of improved insulin sensitivity. Fetuin-A, which is known to inhibit insulin signalling, has emerged as a biomarker for diabetes risk. Alcohol consumption may influence circulating fetuin-A concentrations and subsequently diabetes risk by altering the insulin signal. We therefore hypothesised that moderate alcohol consumption would be associated with lower fetuin-A concentration and that fetuin-A would partly explain the association between alcohol consumption and incident type 2 diabetes.
methodsAmong diabetes-free female participants in the Nurses' Health Study (n = 1,331), multiple linear regression was conducted to assess the association between alcohol consumption and plasma fetuin-A. Least-squares means (lsmeans) of fetuin-A were estimated in categories of alcohol consumption (0, 0.1-4.9, 5-14.9 and ≥ 15 g/day). The proportion of alcohol consumption and diabetes association explained by baseline fetuin-A was assessed in 470 matched incident diabetes case-control pairs with follow-up 2000-2006.
resultsHigher alcohol consumption was associated with lower plasma fetuin-A (p for trend = 0.009): lsmean ± SE 476.5 ± 5.9 μg/ml for abstainers, 468.9 ± 5.2 μg/ml for 0.1-4.9 g/day consumers, 455.9 ± 7.0 μg/ml for 5.0-14.9 g/day consumers, and 450.0 ± 9.4 μg/ml for ≥ 15.0 g/day consumers. Fetuin-A and fasting insulin explained 18.4% and 54.8%, respectively, of the inverse association between alcohol consumption and diabetes after multiple adjustment (both p for contribution <0.04). CONCLUSIONS/
interpretationModerate alcohol consumption is associated with lower plasma fetuin-A in diabetes-free women. Fetuin-A and insulin explain a significant proportion of the association between alcohol consumption and incident type 2 diabetes. Further studies are needed to examine potential biological mechanisms underlying this association.
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