ArticleDiseases of the colon and rectum2013
Serrated polyposis: colonic phenotype, extracolonic features, and familial risk in a large cohort.
Article in Diseases of the colon and rectum, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 40 citations in OpenAlex.
- Germline Variants in DNA Interstrand-Cross Link Repair Genes May Contribute to Increased Susceptibility for Serrated Polyposis Syndrome.International journal of molecular sciences · 2024Article
- The Largest Chinese Cohort Study Indicates Homologous Recombination Pathway Gene Mutations as Another Major Genetic Risk Factor for Colorectal Cancer with Heterogeneous Clinical Phenotypes.Research (Washington, D.C.) · 2023Article
- Synchronized early gastric cancer occurred in a patient with serrated polyposis syndrome: A case report.World journal of clinical cases · 2022Article
- Novel Genetic Causes of Gastrointestinal Polyposis Syndromes.The application of clinical genetics · 2021Review
- Diagnosis, epidemiology and management of serrated polyposis syndrome: a comprehensive review of the literature.American journal of translational research · 2021Review
- Hereditary or Not? Understanding Serrated Polyposis Syndrome.Current treatment options in gastroenterology · 2019Review
- Small RNA sequencing of sessile serrated polyps identifies microRNA profile associated with colon cancer.Genes, chromosomes & cancer · 2019Article
- Management of Serrated Polyps of the Colon.Current treatment options in gastroenterology · 2018Review
- Serrated Polyposis Syndrome in a Single-Center 10-Year Experience.Balkan medical journal · 2018Article
- Hereditary Colorectal Polyposis and Cancer Syndromes: A Primer on Diagnosis and Management.The American journal of gastroenterology · 2017Review
- Clinical characteristics of patients with serrated polyposis syndrome in Korea: comparison with Western patients.Intestinal research · 2017Article
- Serrated polyposis associated with a family history of colorectal cancer and/or polyps: The preferential location of polyps in the colon and rectum defines two molecular entities.International journal of molecular medicine · 2016Article
- Gene Signature in Sessile Serrated Polyps Identifies Colon Cancer Subtype.Cancer prevention research (Philadelphia, Pa.) · 2016Article
- Risk of Colorectal and Other Cancers in Patients With Serrated Polyposis.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2015Article
- Clinical management of hereditary colorectal cancer syndromes.Nature reviews. Gastroenterology & hepatology · 2015Review
- Clinicopathological Characteristics of Serrated Polyposis Syndrome in Korea: Single Center Experience.Gastroenterology research and practice · 2015Article
- The evolution of colorectal cancer genetics-Part 2: clinical implications and applications.Journal of gastrointestinal oncology · 2014Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundSerrated polyposis is a poorly understood and likely underdiagnosed condition. Little is known regarding the colorectal cancer risk, extracolonic phenotype, and cause of serrated polyposis.
objectiveThe aim of this study is to describe the clinical and family history features of a large cohort of individuals with serrated polyposis.
designThis is a retrospective cohort study from 2 prospectively collected registries. PATIENTS: Patients meeting the updated 2010 World Health Organization criteria for serrated polyposis were included.
main outcome measuresWe report descriptive statistics for clinical and family history factors.
resultsA total of 52 individuals met criteria for serrated polyposis. Of these, one had Lynch syndrome and was not included in the statistical analyses. Median age at serrated polyposis diagnosis was 51 years (range, 18-77). Twenty-four (47%) patients were male, and 25 (49%) had a history of smoking. Two hundred sixty-eight lower endoscopic procedures were performed; 42 (82%) patients had colorectal adenomas, 8 (16%) had a personal history of colorectal cancer (only 1 was diagnosed during follow-up), 12 (24%) had extracolonic tumors (4 had more than 1 primary tumor), and 19 (37%) reported a family history of colorectal cancer. Esophagogastroduodenoscopy in 30 individuals revealed only 1 (3%) with unexplained gastroduodenal polyps. No association was found between colorectal cancer diagnosis and sex, age at serrated polyposis diagnosis, extracolonic tumor, history of adenoma, or smoking status. LIMITATIONS: This was a retrospective study with no comparison groups.
conclusionsGastroduodenal polyps are uncommon and likely not associated with serrated polyposis. Although extracolonic tumors were common in our cohort, it is still unclear whether these are associated with serrated polyposis. Our data, along with previous studies, support an association between serrated polyposis and smoking. Further work is still needed to clarify the effect of smoking on polyp development/progression in serrated polyposis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.