Evidence map›Paper›PMID 24104965›Full record

ArticleBritish journal of cancer2013

Identification of serum miRNAs as novel non-invasive biomarkers for detection of high risk for early gastric cancer.

A Shiotani, T Murao, Y Kimura, H Matsumoto, T Kamada, H Kusunoki, K Inoue, N Uedo, H Iishi, K Haruma

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of cancer, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed, 10 pooled it
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 10 syntheses or guidelines pooled it, 91 citations in OpenAlex.

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  5. MicroRNA-17 family as novel biomarkers for cancer diagnosis: a meta-analysis based on 19 articles.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016
    Pooled it
  6. The clinical value of ncRNAs in gastric cancer: a systematic review and meta-analyses.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015
    Pooled it
  7. The clinical utility of microRNA-21 as novel biomarker for diagnosing human cancers.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015
    Pooled it
  8. Circulating microRNA-21 as a biomarker for the detection of various carcinomas: an updated meta-analysis based on 36 studies.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015
    Pooled it
  9. Diagnostic value of circulating microRNAs for gastric cancer in Asian populations: a meta-analysis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014
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  11. Rethinking Oxidative Stress inLife (Basel, Switzerland) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

A ShiotaniDivision of Gastroenterology, Department of Internal Medicine, Kawasaki Medical School, Kurashiki, Japan.
T Murao
Y Kimura
H Matsumoto
T Kamada
H Kusunoki
K Inoue
N Uedo
H Iishi
K Haruma
Kawasaki Medical School · JPOsaka Medical Center for Cancer and Cardiovascular Diseases · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMany micro-RNAs (miRNAs) are differentially expressed in Helicobacter pylori-infected gastric mucosa and in gastric cancer tissue and previous reports have suggested the possibility of serum miRNAs as complementary tumour markers. The aim of the study was to investigate serum miRNAs and pepsinogen levels in individuals at high risk for gastric cancer both before and after H. pylori eradication.

methodsPatients with recent history of endoscopic resection for early gastric cancer and the sex- and age-matched controls were enrolled. Serum was collected from subjects before or after eradication and total RNA was extracted to analyse serum levels of 24 miRNAs. Serum pepsinogen (PG) I and II levels were measured using enzyme-linked immunosorbent assay kits.

resultsUsing miR-16 as an endogenous control, the relative levels of miR-106 and let-7d before and after H. pylori eradication and miR-21 after eradication were significantly higher in the high-risk group than in the controls. H. pylori eradication significantly decreased miR-106b levels and increased let-7d only in the control group. After eradication, the combination MiR-106b with miR-21 was superior to serum pepsinogen and the most valuable biomarker for the differentiating high-risk group from controls.

conclusionSerum miR-106b and miR-21 may provide a novel and stable marker of increased risk for early gastric cancer after H. pylori eradication.

Indexed as

AgedBiomarkers, TumorCase-Control StudiesFemaleGastric MucosaHelicobacter InfectionsHelicobacter pyloriHumansMaleMicroRNAsPepsinogen APepsinogen CStomach NeoplasmsBiomarkers, TumorMicroRNAsMIRN106 microRNA, humanMIRN21 microRNA, humanPepsinogen APepsinogen C

Identifiers

PMID24104965
PMCPMC3817334
OpenAlexW1999589813

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.