ArticleBritish journal of cancer2013
MicroRNA-based molecular classification of non-BRCA1/2 hereditary breast tumours.
Article in British journal of cancer, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Topology preserving stratification of tissue neoplasticity using Deep Neural Maps and microRNA signatures.BMC bioinformatics · 2022Article
- MicroRNA-548m Suppresses Cell Migration and Invasion by Targeting Aryl Hydrocarbon Receptor in Breast Cancer Cells.Oncology research · 2021Article
- The Implications of ncRNAs in the Development of Human Diseases.Non-coding RNA · 2021Review
- MiR-29b-1-5p is altered in BRCA1 mutant tumours and is a biomarker in basal-like breast cancer.Oncotarget · 2018Article
- Genetic alterations detected by comparative genomic hybridization in BRCAX breast and ovarian cancers of Brazilian population.Oncotarget · 2018Article
- Single-base LOH can be used as Specific Marker to Classify BRCAx Familial Breast Cancer into More Homogenous Subtypes.The breast journal · 2017Article
- Bias in microRNA functional enrichment analysis.Bioinformatics (Oxford, England) · 2015Article
- miRNA expression profiling of formalin-fixed paraffin-embedded (FFPE) hereditary breast tumors.Genomics data · 2015Article
- miRGate: a curated database of human, mouse and rat miRNA-mRNA targets.Database : the journal of biological databases and curation · 2015Article
- MiR-578 and miR-573 as potential players in BRCA-related breast cancer angiogenesis.Oncotarget · 2015Article
- MicroRNA expression profiling in male and female familial breast cancer.British journal of cancer · 2014Article
- Combined microRNA and ER expression: a new classifier for familial and sporadic breast cancer patients.Journal of translational medicine · 2014Article
- Sparse representation for tumor classification based on feature extraction using latent low-rank representation.BioMed research international · 2014Article
- MicroRNAs discriminate familial from sporadic non-BRCA1/2 breast carcinoma arising in patients ≤35 years.PloS one · 2014Article
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9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHereditary breast cancer comprises 5-10% of all breast cancers. Mutations in two high-risk susceptibility genes, BRCA1 and BRCA2, along with rare intermediate-risk genes and common low-penetrance alleles identified, altogether explain no more than 45% of the high-risk breast cancer families, although the majority of cases are unaccounted for and are designated as BRCAX tumours. Micro RNAs have called great attention for classification of different cancer types and have been implicated in a range of important biological processes and are deregulated in cancer pathogenesis.
methodsHere we have performed an exploratory hypothesis-generating study of miRNA expression profiles in a large series of 66 primary hereditary breast tumours by microarray analysis.
resultsUnsupervised clustering analysis of miRNA molecular profiles revealed distinct subgroups of BRCAX tumours, 'normal-like' BRCAX-A, 'proliferative' BRCAX-B, 'BRCA1/2-like' BRCAX-C and 'undefined' BRCAX-D subgroup. These findings introduce a new insight in the biology of hereditary breast cancer, defining specific BRCAX subgroups, which could help in the search for novel susceptibility pathways in hereditary breast cancer.
conclusionOur data demonstrate that BRCAX hereditary breast tumours can be sub-classified into four previously unknown homogenous groups characterised by specific miRNA expression signatures and histopathological features.
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