ArticleMolecular systems biology2013
Temporal control of self-organized pattern formation without morphogen gradients in bacteria.
Article in Molecular systems biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
58 citing papers in PubMed, 129 citations in OpenAlex.
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- Spatial proximity dictates bacterial competition and expansion in microbial communities.Nature communications · 2025Article
- Partitioning of a 2-bit hash function across 66 communicating cells.Nature chemical biology · 2025Article
- Adaptive and Dissipative Hierarchical Population Crowding of Synthetic Protocells through Click-PISA under Gradient Energy Inputs.Nano letters · 2024Article
- Spatial biology of Ising-like synthetic genetic networks.BMC biology · 2023Article
- Engineering living materials by synthetic biology.Biophysics reviews · 2023Review
- Characterizing the Impact of Communication on Cellular and Collective Behavior Using a Three-Dimensional Multiscale Cellular Model.Entropy (Basel, Switzerland) · 2023Article
- Spatiotemporal Patterning Enabled by Gene Regulatory Networks.ACS omega · 2023Article
- Distributed information encoding and decoding using self-organized spatial patterns.Patterns (New York, N.Y.) · 2022Article
- Self-organized canals enable long-range directed material transport in bacterial communities.eLife · 2022Article
- Engineered Living Hydrogels.Advanced materials (Deerfield Beach, Fla.) · 2022Review
- Advances and challenges in programming pattern formation using living cells.Current opinion in chemical biology · 2022Review
- Synthetic spatial patterning in bacteria: advances based on novel diffusible signals.Microbial biotechnology · 2022Review
- Article
- Synthetic biology as driver for the biologization of materials sciences.Materials today. Bio · 2021Review
- Applications, challenges, and needs for employing synthetic biology beyond the lab.Nature communications · 2021Review
- Repulsive expansion dynamics in colony growth and gene expression.PLoS computational biology · 2021Article
- Interpretation of morphogen gradients by a synthetic bistable circuit.Nature communications · 2020Article
- Turing Patterning in Stratified Domains.Bulletin of mathematical biology · 2020Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Diverse mechanisms have been proposed to explain biological pattern formation. Regardless of their specific molecular interactions, the majority of these mechanisms require morphogen gradients as the spatial cue, which are either predefined or generated as a part of the patterning process. However, using Escherichia coli programmed by a synthetic gene circuit, we demonstrate here the generation of robust, self-organized ring patterns of gene expression in the absence of an apparent morphogen gradient. Instead of being a spatial cue, the morphogen serves as a timing cue to trigger the formation and maintenance of the ring patterns. The timing mechanism enables the system to sense the domain size of the environment and generate patterns that scale accordingly. Our work defines a novel mechanism of pattern formation that has implications for understanding natural developmental processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.