ArticleRadiation oncology (London, England)2013
Radiotherapy in langerhans cell histiocytosis - a rare indication in a rare disease.
Article in Radiation oncology (London, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 40 citations in OpenAlex.
- What to do to beat Langerhans cell histiocytosis of bone? A narrative review and case series of radiofrequency ablation.EFORT open reviews · 2026Review
- [A case of adult temporal bone langerhans cell histiocytosis presenting as posterior canal dehiscence syndrome and literature review].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2025Review
- Unraveling cutaneous histiocytosis: insights into histology, pathogenesis, diagnosis, and treatment pitfalls.Frontiers in medicine · 2025Review
- Clinical features and pathological analysis of primary rib Langerhans cell histiocytosis: case series and literature review.AME case reports · 2025Article
- Stereotactic radiosurgery for intracranial Langerhans cell histiocytosis: A multi-institutional case series with long-term follow-up.Brain & spine · 2025Article
- Langerhans cell histiocytosis of the skull in 23 children.European journal of medical research · 2024Article
- A case of adult multisystem Langerhans histiocytosis successfully treated by smoking cessation and radiotherapy for bone lesion.Clinical case reports · 2022Article
- Aggressive unifocal bone Langerhans cell histiocytosis with soft tissue extension both responsive to radiotherapy: a case report.Radiation oncology (London, England) · 2022Article
- Article
- Adult Langerhans Cell Histiocytosis and the Skeleton.Journal of clinical medicine · 2022Review
- Three-dimensional printed titanium pseudo-prosthesis for the treatment of a tumoral bone defect.JSES reviews, reports, and techniques · 2022Article
- Isolated Bone Lesions in the Mandible and Maxilla of Langerhans Cell Histiocytosis Treated with Fractionated Stereotactic Low-Dose Radiotherapy: Case Report and 5-Year Follow-Up.Case reports in dentistry · 2021Article
- A Dose-Response Relationship to Radiotherapy for Cutaneous Lesions of Langerhans Cell Histiocytosis.Case reports in oncological medicine · 2021Article
- Langerhans cell histiocytosis: A case report with oral manifestations and the role of pediatric dentists in the diagnosis.Clinical case reports · 2020Article
- Oral manifestation of Langerhans cell histiocytosis: a case report.BMC oral health · 2018Article
- Outcome After Radiation Therapy for Langerhans Cell Histiocytosis Is Dependent on Site of Involvement.International journal of radiation oncology, biology, physics · 2018Article
- Radiotherapy for aneurysmal bone cysts : A rare indication.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2017Review
- Langerhans' cell histiocytosis of the temporal fossa: A case report.Oncology letters · 2016Article
- Article
- Langerhans cell histiocytosis of the sacrum.Radiology case reports · 2014Article
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Authors and funding
9 authors at 8 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionLangerhans Cell Histiocytosis (LCH) represents a rare benign disorder, previously designated as "Histiocytosis X", "Type II Histiocytosis" or "Langerhans Cell Granulomatosis". Clinical presentation includes osteolysis, ulcerations of skin and soft tissues but also involvement of the CNS is described.Because treatment concepts are not well defined the German Cooperative Group on Radiotherapy for Benign Diseases performed a retrospective analysis. METHODS AND MATERIAL: Eight closely cooperating centres collected patients' data of the past 45 years. As study endpoints disease free survival, recurrent disease, death and therapy related side effects were defined.
resultsA total of 80 patients with histologically proven LCH were irradiated within the past 45 years. According to the LCH classification of Greenberger et al. 37 patients had stage Ia, 21 patients stage Ib, 13 patients stage II and 9 patients stage IIIb and the median age was 29 years. The median Follow up was 54 months (range 9-134 months). A total of 39 patients had a surgical intervention and 23 patients a chemotherapy regimen.Radiation treatment was carried out with a median total dose of 15 Gy (range 3-50.4 Gy). The median single fraction was 2 Gy (range 1.8-3 Gy).Overall, 77% patients achieved a complete remission and 12.5% achieved a partial remission. The long-term control rate reached 80%. Within an actuarial overall 5-year survival of 90% no radiogenic side and late effects ≥EORTC/RTOG II° were observed.
conclusionIn the present study a large collective of irradiated patients was analysed. Radiotherapy (RT) is a very effective and safe treatment option and even low RT doses show sufficient local control.
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