ArticleToxicology and applied pharmacology2013
Ozone induces glucose intolerance and systemic metabolic effects in young and aged Brown Norway rats.
Article in Toxicology and applied pharmacology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 1 of them a synthesis that pooled it.
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Who cites it
67 citing papers in PubMed, 1 synthesis or guideline pooled it, 109 citations in OpenAlex.
- Air pollution and gestational diabetes mellitus: evidence from cohort studies.BMJ open diabetes research & care · 2020Pooled it
- Changes in Metabolites Present in Lung-Lining Fluid Following Exposure of Humans to Ozone.Toxicological sciences : an official journal of the Society of Toxicology · 2018Trial
- Long-term and short-term exposure to outdoor air pollution and its association with glycolipid metabolic disorders.World journal of diabetes · 2025Article
- Ozone Exposure Induces Prediabetic Symptoms Through Hepatic Glycogen Metabolism and Insulin Resistance.Toxics · 2025Article
- Adrenergic receptor subtypes differentially influence acrolein-induced ventilatory, vascular leakage, and inflammatory responses.Toxicology and applied pharmacology · 2025Article
- Neuroimmune axis: Linking environmental factors to pancreatic β-cell dysfunction in Diabetes.Brain, behavior, & immunity - health · 2025Article
- Ozone exposure and cardiovascular disease: A narrative review of epidemiology evidence and underlying mechanisms.Fundamental research · 2025Review
- Exposure to air pollution is associated with adipokines in midlife women: The Study of Women's Health Across the Nation.The Science of the total environment · 2024Article
- Mechanistic insights regarding neuropsychiatric and neuropathologic impacts of air pollution.Critical reviews in toxicology · 2024Review
- Subacute Exposure to Gaseous Pollutants from Diesel Engine Exhaust Attenuates Capsaicin-Induced Cardio-Pulmonary Reflex Responses Involving Oxidant Stress Mechanisms in Adult Wistar Rats.Cardiovascular toxicology · 2024Article
- Preliminary study on the effect of ozone exposure on blood glucose level in rats.Technology and health care : official journal of the European Society for Engineering and Medicine · 2023Article
- Stress Drivers of Glucose Dynamics during Ozone Exposure Measured Using Radiotelemetry in Rats.Environmental health perspectives · 2022Article
- Adrenal Stress Hormone Regulation of Hepatic Homeostatic Function After an Acute Ozone Exposure in Wistar-Kyoto Male Rats.Toxicological sciences : an official journal of the Society of Toxicology · 2022Article
- The contribution of the neuroendocrine system to adaption after repeated daily ozone exposure in rats.Toxicology and applied pharmacology · 2022Article
- Ozone Exposure, Outdoor Physical Activity, and Incident Type 2 Diabetes in the SALSA Cohort of Older Mexican Americans.Environmental health perspectives · 2021Article
- The dynamicity of acute ozone-induced systemic leukocyte trafficking and adrenal-derived stress hormones.Toxicology · 2021Article
- Adrenergic and Glucocorticoid Receptors in the Pulmonary Health Effects of Air Pollution.Toxics · 2021Review
- The Role of Hepatic Vagal Tone in Ozone-Induced Metabolic Dysfunction in the Liver.Toxicological sciences : an official journal of the Society of Toxicology · 2021Article
- Ozone-induced acute phase response in lung versus liver: the role of adrenal-derived stress hormones.Journal of toxicology and environmental health. Part A · 2021Article
- Peripheral metabolic effects of ozone exposure in healthy and diabetic rats on normal or high-cholesterol diet.Toxicology and applied pharmacology · 2021Article
7 more citing papers are in PubMed but not listed here.
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
Abstract
Air pollutants have been associated with increased diabetes in humans. We hypothesized that ozone would impair glucose homeostasis by altering insulin signaling and/or endoplasmic reticular (ER) stress in young and aged rats. One, 4, 12, and 24 month old Brown Norway (BN) rats were exposed to air or ozone, 0.25 or 1.0 ppm, 6 h/day for 2 days (acute) or 2 d/week for 13 weeks (subchronic). Additionally, 4 month old rats were exposed to air or 1.0 ppm ozone, 6 h/day for 1 or 2 days (time-course). Glucose tolerance tests (GTT) were performed immediately after exposure. Serum and tissue biomarkers were analyzed 18 h after final ozone for acute and subchronic studies, and immediately after each day of exposure in the time-course study. Age-related glucose intolerance and increases in metabolic biomarkers were apparent at baseline. Acute ozone caused hyperglycemia and glucose intolerance in rats of all ages. Ozone-induced glucose intolerance was reduced in rats exposed for 13 weeks. Acute, but not subchronic ozone increased α2-macroglobulin, adiponectin and osteopontin. Time-course analysis indicated glucose intolerance at days 1 and 2 (2>1), and a recovery 18 h post ozone. Leptin increased day 1 and epinephrine at all times after ozone. Ozone tended to decrease phosphorylated insulin receptor substrate-1 in liver and adipose tissues. ER stress appeared to be the consequence of ozone induced acute metabolic impairment since transcriptional markers of ER stress increased only after 2 days of ozone. In conclusion, acute ozone exposure induces marked systemic metabolic impairments in BN rats of all ages, likely through sympathetic stimulation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.