ReviewThe international journal of neuropsychopharmacology2014
Genetic approaches to understanding post-traumatic stress disorder.
Review in The international journal of neuropsychopharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Meta-Analysis of Associations Between Hypothalamic-Pituitary-Adrenal Axis Genes and Risk of Posttraumatic Stress Disorder.Journal of traumatic stress · 2020Pooled it
- Association of Posttraumatic Stress Disorder With rs2267735 in the ADCYAP1R1 Gene: A Meta-Analysis.Journal of traumatic stress · 2017Pooled it
- The Association Between Genetic Variants in the Dopaminergic System and Posttraumatic Stress Disorder: A Meta-Analysis.Medicine · 2016Pooled it
- The catecholamine biosynthetic enzyme dopamine β-hydroxylase (DBH): first genome-wide search positions trait-determining variants acting additively in the proximal promoter.Human molecular genetics · 2014Pooled it
- Pre-trauma cognitive traits predict fear generalization and associated prefrontal functioning in a longitudinal rodent model.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- The frequency and correlates of complex post-traumatic stress disorder among patients being treated for borderline personality disorder: cross-sectional study.BJPsych open · 2025Article
- Epigenetic Echoes: Bridging Nature, Nurture, and Healing Across Generations.International journal of molecular sciences · 2025Review
- The prevalence of posttraumatic stress disorder and its correlation with health beliefs among medical students.Journal of education and health promotion · 2025Article
- The predictive, preventive, and personalized medicine of insomnia: gut microbiota and inflammation.The EPMA journal · 2023Article
- Insights into the Involvement and Therapeutic Target Potential of the Dopamine System in the Posttraumatic Stress Disorder.Molecular neurobiology · 2023Review
- Neurobiology of Aggression-Review of Recent Findings and Relationship with Alcohol and Trauma.Biology · 2023Review
- To Predict, Prevent, and Manage Post-Traumatic Stress Disorder (PTSD): A Review of Pathophysiology, Treatment, and Biomarkers.International journal of molecular sciences · 2023Review
- Genetic variants associated with post-traumatic stress symptoms in patients with gynecologic cancer.Gynecologic oncology · 2023Article
- Anti-Inflammatory Therapy as a Promising Target in Neuropsychiatric Disorders.Advances in experimental medicine and biology · 2023Review
- A Public Health Perspective of Post-Traumatic Stress Disorder.International journal of environmental research and public health · 2022Review
- The Molecular Biology of Susceptibility to Post-Traumatic Stress Disorder: Highlights of Epigenetics and Epigenomics.International journal of molecular sciences · 2021Review
- Title: "Labels Matter: Is it stress or is it Trauma?"Translational psychiatry · 2021Review
- Possible Association of Polymorphisms in Ubiquitin Specific Peptidase 46 Gene With Post-traumatic Stress Disorder.Frontiers in psychiatry · 2021Article
- Using Monozygotic Twins to Dissect Common Genes in Posttraumatic Stress Disorder and Migraine.Frontiers in neuroscience · 2021Article
- A review of epigenetic contributions to post-traumatic stress disorder .Dialogues in clinical neuroscience · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Post-traumatic stress disorder (PTSD) is increasingly recognized as both a disorder of enormous mental health and societal burden, but also as an anxiety disorder that may be particularly understandable from a scientific perspective. Specifically, PTSD can be conceptualized as a disorder of fear and stress dysregulation, and the neural circuitry underlying these pathways in both animals and humans are becoming increasingly well understood. Furthermore, PTSD is the only disorder in psychiatry in which the initiating factor, the trauma exposure, can be identified. Thus, the pathophysiology of the fear and stress response underlying PTSD can be examined and potentially interrupted. Twin studies have shown that the development of PTSD following a trauma is heritable, and that genetic risk factors may account for up to 30-40% of this heritability. A current goal is to understand the gene pathways that are associated with PTSD, and how those genes act on the fear/stress circuitry to mediate risk vs. resilience for PTSD. This review will examine gene pathways that have recently been analysed, primarily through candidate gene studies (including neuroimaging studies of candidate genes), in addition to genome-wide associations and the epigenetic regulation of PTSD. Future and on-going studies are utilizing larger and collaborative cohorts to identify novel gene candidates through genome-wide association and other powerful genomic approaches. Identification of PTSD biological pathways strengthens the hope of progress in the mechanistic understanding of a model psychiatric disorder and allows for the development of targeted treatments and interventions.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.