ArticleThe European journal of neuroscience2013
Functional integrity of the habenula is necessary for social play behaviour in rats.
Article in The European journal of neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- Deep Brain Stimulation of the Habenula: Systematic Review of the Literature and Clinical Trial Registries.Frontiers in psychiatry · 2021Pooled it
- Habenula Alterations in Resting-State Functional Connectivity Among Autistic Individuals.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- A depression-like phenotype is associated with discrete defects in the primary hippocampal circuit.Translational psychiatry · 2026Article
- The lateral habenula as a master regulator of innate and learned social behaviors.Psychopharmacology · 2026Review
- Early life social isolation stress and pain vulnerability: unraveling neuroimmune mechanisms and central sensitization.Frontiers in pharmacology · 2026Review
- Neural activation in a septal area is related to intrinsic motivation for non-courtship singing in adult zebra finches.Scientific reports · 2025Article
- Disrupted functional connectome in a rodent model of autism during social isolation.Frontiers in neural circuits · 2025Article
- Hyperthermia elevates brain temperature and improves behavioural signs in animal models of autism spectrum disorder.Molecular autism · 2023Article
- The Roles of Histamine Receptor 1 (hrh1) in Neurotransmitter System Regulation, Behavior, and Neurogenesis in Zebrafish.Molecular neurobiology · 2023Article
- Social play behavior shapes the development of prefrontal inhibition in a region-specific manner.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Social and asocial learning in zebrafish are encoded by a shared brain network that is differentially modulated by local activation.Communications biology · 2023Article
- The role of orphan receptor GPR139 in neuropsychiatric behavior.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Habenular Involvement in Response to Subcallosal Cingulate Deep Brain Stimulation for Depression.Frontiers in psychiatry · 2022Article
- Editorial: The Habenula and Its Role in Neuropsychiatric Symptoms.Frontiers in behavioral neuroscience · 2022Article
- Involvement of the habenula in the pathophysiology of autism spectrum disorder.Scientific reports · 2021Article
- Altered expression of lncRNAs in autism spectrum disorder.Metabolic brain disease · 2021Article
- Role of Habenula in Social and Reproductive Behaviors in Fish: Comparison With Mammals.Frontiers in behavioral neuroscience · 2021Review
- From controlled to compulsive drug-taking: The role of the habenula in addiction.Neuroscience and biobehavioral reviews · 2019Review
- The zebrafish subcortical social brain as a model for studying social behavior disorders.Disease models & mechanisms · 2019Review
- An Adult Brain Atlas Reveals Broad Neuroanatomical Changes in Independently Evolved Populations of Mexican Cavefish.Frontiers in neuroanatomy · 2019Article
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
During post-weaning development, a marked increase in peer-peer interactions is observed in mammals, including humans, which is signified by the abundance of social play behaviour. Social play is highly rewarding, and known to be modulated through monoaminergic neurotransmission. Recently, the habenula has received widespread attention because of its role in the regulation of monoaminergic neurotransmission as well as in a variety of emotional and cognitive functions. Therefore, in the present study, we investigated the involvement of the habenula in social play behaviour. Using the neuronal activity maker c-fos, we showed that the habenula was activated after 24 h of social isolation in adolescent rats, and that a subsequent social play interaction reduced c-fos activity in the medial part of the lateral habenula. This suggested that habenula activity modulated the aversive properties of social isolation, which was alleviated by the positive effects of social play. Furthermore, after functional inactivation of the habenula, using a mixture of the GABA receptor agonists baclofen and muscimol, social play behaviour was markedly reduced, whereby responsiveness to play solicitation was more sensitive to habenula inactivation than play solicitation itself. Together, our data indicate an important role for the habenula in the processing of positive (i.e., social play behaviour) and negative (i.e., social isolation) social information in adolescent rats. Altered habenula function might therefore be related to the social impairments in childhood and adolescent psychiatric disorders such as autism, attention deficit/hyperactivity disorder and early-onset schizophrenia.
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