ArticleBritish journal of clinical pharmacology2014
Usage patterns of 'over-the-counter' vs. prescription-strength nonsteroidal anti-inflammatory drugs in France.
Article in British journal of clinical pharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- The Impact of Baseline Pain Intensity on the Analgesic Efficacy of Ibuprofen/Caffeine in Patients with Acute Postoperative Dental Pain: Post Hoc Subgroup Analysis of a Randomised Controlled Trial.Advances in therapy · 2020Trial
- Structural and Functional Changes in Biological Systems of Wastewater Treatment Plants Induced by Bicyclic Non-Steroidal Anti-Inflammatory Drugs-A Review.Molecules (Basel, Switzerland) · 2026Review
- Knowledge, attitudes, and practices of pharmacists toward over-the-counter medication use in Iraq: a nationwide cross-sectional study.Frontiers in pharmacology · 2025Article
- Article
- Trends in harmful drug exposure during pregnancy in France between 2013 and 2019: A nationwide cohort study.PloS one · 2024Article
- An Update on Nonsteroidal Anti-Inflammatory Drug-Induced Urticaria.Endocrine, metabolic & immune disorders drug targets · 2024Review
- Consumer awareness and knowledge regarding use of non-steroidal anti-inflammatory drugs (NSAIDs) in a metropolitan area.Frontiers in pharmacology · 2024Article
- Pattern of use and awareness of side-effects of non-steroidal anti-inflammatory drugs in the Jordanian population.Annals of medicine · 2023Article
- Identifying Non-Steroidal Anti-Inflammatory Drug (NSAID) Users Among People with Osteoarthritis Through Administrative and Clinician-Reported Data - A Validation Study of 116,162 Patients.Clinical epidemiology · 2023Article
- Comparison of paracetamol and diclofenac prescribing preferences for adults in primary care.Primary health care research & development · 2021Article
- Genetic Variants in Cytosolic Phospholipase A2 Associated With Nonsteroidal Anti-Inflammatory Drug-Induced Acute Urticaria/Angioedema.Frontiers in pharmacology · 2021Article
- Potential for Detection of Safety Signals for Over-the-Counter Medicines Using National ADR Spontaneous Reporting Data: The Example of OTC NSAID-Associated Gastrointestinal Bleeding.Pharmacy (Basel, Switzerland) · 2020Article
- Does Ibuprofen Worsen COVID-19?Drug safety · 2020Article
- A Randomized, Double-Blind, Placebo-Controlled Trial of Ibuprofen Lysinate in Comparison to Ibuprofen Acid for Acute Postoperative Dental Pain.Pain and therapy · 2020Article
- Coronary Risks Associated with Diclofenac and Other NSAIDs: An Update.Drug safety · 2020Review
- Platelet-Adherent Leukocytes Associated With Cutaneous Cross-Reactive Hypersensitivity to Nonsteroidal Anti-Inflammatory Drugs.Frontiers in pharmacology · 2020Article
- Previous Drug Exposure in Patients Hospitalised for Acute Liver Injury: A Case-Population Study in the French National Healthcare Data System.Drug safety · 2019Article
- Coronary Events After Dispensing of Ibuprofen: A Propensity Score-Matched Cohort Study Versus Paracetamol in the French Nationwide Claims Database Sample.Drug safety · 2018Article
- Association between inflammation and systolic blood pressure in RA compared to patients without RA.Arthritis research & therapy · 2018Article
- Comparative cardiovascular safety of nonsteroidal anti-inflammatory drugs in patients with hypertension: a population-based cohort study.British journal of clinical pharmacology · 2018Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsMost risks of nonsteroidal anti-inflammatory drugs (NSAIDs) are pharmacological, dose and duration dependent. Usage patterns of prescription-only (POM) or 'over-the-counter (OTC)' NSAIDs may influence risks, but are not commonly described.
methodsThe Echantillon Généraliste de Bénéficiaires database, the permanent 1/97 representative sample from the French national healthcare insurance systems, was queried over 2009-2010 to identify usage patterns, concomitant chronic diseases and cardiovascular medication in OTC and POM NSAID users.
resultsOver 2 years, 229 477 of 526 108 patients had at least one NSAID dispensation; 44 484 patients (19%) were dispensed only OTC NSAIDs (93% ibuprofen) and 121 208 (53%) only POM NSAIDs. The OTC users were younger (39.9 vs. 47.4 years old) and more often female (57 vs. 53%); 69% of OTC users and 49% of POM users had only one dispensation. A mean of 14.6 defined daily doses (DDD) were dispensed over 2 years for OTC vs. 53 for POM; 93% OTC vs. 60% POM patients bought ≤ 30 DDD over 2 years, and 1.5 vs. 12% bought ≥ 90 DDD. Chronic comorbidities were found in 19% of OTC users vs. 28% of POM users; 24 vs. 37% had at least one dispensation of a cardiovascular drug over the 2 years.
conclusionsMost of the use of NSAIDs appears to be short term, especially for OTC-type NSAIDs, such as ibuprofen. The validity of risk estimates for NSAIDs extrapolated from clinical trials or from observational studies not including OTC-type usage may need to be revised.
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