ArticleMitochondrial DNA2015
Mitochondrial DNA diversity in the African American population.
Article in Mitochondrial DNA, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Association of mitochondrial DNA haplogroup, oxidative DNA damage and inflammatory markers in middle-aged adults.International journal of radiation biology · 2026Article
- Review
- Community-engaged ancient DNA project reveals diverse origins of 18th-century African descendants in Charleston, South Carolina.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Mitochondrial DNA and Alzheimer's disease: a first case-control study of the Tunisian population.Molecular biology reports · 2022Article
- Validation of low-coverage whole-genome sequencing for mitochondrial DNA variants suggests mitochondrial DNA as a genetic cause of preterm birth.Human mutation · 2021Article
- Development of a NovelFrontiers in cellular and infection microbiology · 2019Article
- Analysis of human mitochondrial DNA sequences from fecally polluted environmental waters as a tool to study population diversity.AIMS environmental science · 2017Article
- Association of primary open-angle glaucoma with mitochondrial variants and haplogroups common in African Americans.Molecular vision · 2016Article
- Mitochondrial DNA variation and virologic and immunological HIV outcomes in African Americans.AIDS (London, England) · 2014Observational
- Confounding by linkage disequilibrium.Journal of human genetics · 2014Review
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Authors and funding
7 authors.
Funding
Abstract
Genetic polymorphism along mitochondrial DNA (mtDNA) defines population-specific signatures called mtDNA haplogroups. Estimation of mtDNA haplogroup distribution may be prone to errors, notably if the study sample is not drawn from a multicenter cohort. Here, we report on mtDNA diversity in a sample of African American individuals (n = 343) enrolled in a multicenter cohort. Sequencing of the hypervariable regions I and II of the D-loop control region showed that the most common mitochondrial variants are 73G, 146C, 150T, 152C, 189G, 16278T, and 16311C. In agreement with the published data, we observed 17 common mtDNA haplogroups: L0, L1, L1b, L1c, L2, L2a, L2b, L2c, L2e, L3, L3b, L3d, L3e, L3f, L3h, L3x, and L4. The most commonly observed haplogroup is L2a (19.8%), followed by L1b (10.2%). Overall, the observed mtDNA haplogroup distribution in our study is similar to those published for the African American and the African populations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.