ArticleContact dermatitis2014
Filaggrin loss-of-function mutations and atopic dermatitis as risk factors for hand eczema in apprentice nurses: part II of a prospective cohort study.
Article in Contact dermatitis, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 75 citations in OpenAlex.
- Different approaches and their consequences for addressing the occupational health and safety of young workers: A systematic narrative literature review.Work (Reading, Mass.) · 2025Pooled it
- Work-related and personal risk factors for occupational contact dermatitis: A systematic review of the literature with meta-analysis.Contact dermatitis · 2023Pooled it
- Integrated Clinical Trial and Molecular Profiling Reveals Immune Drivers of Chronic Hand Eczema.Allergy · 2026Trial
- Trial
- Vocational Guidance for Young Patients with Atopic Dermatitis: A Survey of Physicians' Opinions and Practices.Acta dermato-venereologica · 2022Article
- Characteristics of hand eczema in final-year apprentice nurses during the COVID-19 pandemic.Contact dermatitis · 2022Article
- Multifaceted MRGPRX2: New insight into the role of mast cells in health and disease.The Journal of allergy and clinical immunology · 2021Review
- How does working in pandemic units affect the risk of occupational hand eczema in healthcare workers during the coronavirus disease-2019 (COVID-19) pandemic: A comparative analysis with nonpandemic units.Contact dermatitis · 2021Article
- Rare occurrence of common filaggrin mutations in Turkish children with food allergy and atopic dermatitisTurkish journal of medical sciences · 2020Article
- Hyperkeratotic hand eczema: Eczema or not?Contact dermatitis · 2020Article
- Molecular Mechanism of Atopic Dermatitis Induction Following Sensitization and Challenge with 2,4-Dinitrochlorobenzene in Mouse Skin Tissue.Toxicological research · 2018Article
- Effect of allergens and irritants on levels of natural moisturizing factor and corneocyte morphology.Contact dermatitis · 2017Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
BACKGROUND/
objectivesEnvironmental exposure and personal susceptibility both contribute to the development of hand eczema. In this study, we investigated the effect of loss-of-function mutations in the filaggrin gene (FLG), atopic dermatitis and wet work exposure on the development of hand eczema in apprentice nurses.
methodsDutch apprentice nurses were genotyped for the four most common FLG mutations; atopic dermatitis and hand eczema history were assessed by questionnaire. Exposure and hand eczema during traineeships were assessed with diary cards.
resultsThe prevalence of hand eczema during traineeships was higher among subjects with a history of hand eczema reported at inclusion. Hand washing during traineeships and at home increased the risk of hand eczema. After adjustment for the effects of exposure and FLG mutations, an odds ratio of 2.5 (90% confidence interval 1.7-3.7) was found for a history of atopic dermatitis. In this study, an increased risk of hand eczema conferred by FLG mutations could not be shown, but subjects with concomitant FLG mutations and atopic dermatitis showed the highest risk of hand eczema during traineeships.
conclusionA history of atopic dermatitis, a history of hand eczema and wet work exposure were the most important factors increasing the risk of hand eczema during traineeships.
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