ArticleBioMed research international2013
Common variant of FTO gene, rs9939609, and obesity in Pakistani females.
Article in BioMed research international, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Impact of fat mass and obesity-associated (FTO) gene variants on adult obesity and overweight: a comprehensive meta-analysis.BMC endocrine disorders · 2026Pooled it
- Comparison of the risk of obesity in the FTO rs9939609 genotype in a multiethnic group in Asia systematic review and meta-analysis.Frontiers in medicine · 2025Pooled it
- Genetic Variants in the Fat Mass and Obesity-Associated Gene and Risk of Obesity/Overweight in Children and Adolescents: A Systematic Review and Meta-Analysis.Endocrinology, diabetes & metabolism · 2024Pooled it
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- Review
- Association of FTO rs9939609 Polymorphism With Obesity and Elevated Glycemic Parameters in a Syrian Population: A Case-Control Study.Journal of diabetes research · 2026Article
- Genetic Risk of MASLD in Mongolians: Role ofCurrent issues in molecular biology · 2025Article
- Genetic association ofJournal of cardiovascular and thoracic research · 2024Article
- Association and interaction of the FTO rs1421085 with overweight/obesity in a sample of Pakistani individuals.Eating and weight disorders : EWD · 2020Article
- Association of theUpsala journal of medical sciences · 2020Article
- FTO rs9939609 A allele influences anthropometric outcome in response to dietary intervention, but not in response to physical exercise program.European journal of nutrition · 2019Article
- Influence ofDiabetes, metabolic syndrome and obesity : targets and therapy · 2018Article
- The (FTO) gene polymorphism is associated with metabolic syndrome risk in Egyptian females: a case- control study.BMC medical genetics · 2017Article
- FTO Gene Associates and Interacts with Obesity Risk, Physical Activity, Energy Intake, and Time Spent Sitting: Pilot Study in a Nigerian Population.Journal of obesity · 2017Article
- Effect of six type II diabetes susceptibility loci and an FTO variant on obesity in Pakistani subjects.European journal of human genetics : EJHG · 2016Observational
- Association of FTO rs9939609 SNP with Obesity and Obesity- Associated Phenotypes in a North Indian Population.Oman medical journal · 2016Article
- Relationships betweenClinical interventions in aging · 2016Article
- Article
- FTO Gene Polymorphism Is Associated with Type 2 Diabetes through Its Effect on Increasing the Maximum BMI in Japanese Men.PloS one · 2016Article
- Effect of the Common Fat Mass and Obesity Associated Gene Variants on Obesity in Pakistani Population: A Case-Control Study.BioMed research international · 2015Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Numerous studies confirmed the association of FTO (fat mass and obesity associated gene) common variant, rs9939609, with obesity in European populations. However, studies in Asian populations revealed conflicting results. We examined the association of rs9939609 variant of FTO gene with obesity and obesity-related anthropometric and metabolic parameters in Pakistani population. Body weight, height, waist circumference, hip circumference, and blood pressure (BP) were measured. BMI and waist-to-hip ratio (WHR) were calculated. Levels of fasting blood glucose (FBG), insulin, leptin, and leptin receptors were measured by enzyme linked immunosorbent assay (ELISA), and homeostasis model assessment of insulin resistance (HOMA-IR) was calculated. The results showed association of FTO gene, rs9939609, with obesity in females (>18 years of age). FTO minor allele increased the risk of obesity by 2.8 times (95% CI = 1.3-6.0) in females. This allele showed association with body weight, BMI, waist circumference, hip circumference, WHR, BP, plasma FBG levels, HOMA-IR, plasma insulin levels, and plasma leptin levels. In conclusion, FTO gene, rs9939609, is associated with BMI and risk of obesity in adult Pakistani females. Association of rs9939609 variant with higher FBG, plasma insulin, and leptin levels indicates that this polymorphism may disturb the metabolism in adult females and predispose them to obesity and type 2 diabetes. However, the above-mentioned findings were not seen in children or males.
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