ArticlePatient preference and adherence2013
Antibody and immune memory persistence post infant hepatitis B vaccination.
Article in Patient preference and adherence, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- Persistence of hepatitis B immune memory until 9-10 years of age following hepatitis B vaccination at birth and DTaP-IPV-HB-PRP∼T vaccination at 2, 4 and 6 months.Human vaccines & immunotherapeutics · 2018Trial
- Long-term immune protection after infant hepatitis B vaccination in children.Human vaccines & immunotherapeutics · 2026Review
- Overview of Hepatitis B Vaccine Non-Response and Associated B Cell Amnesia: A Scoping Review.Pathogens (Basel, Switzerland) · 2024Article
- Article
- Article
- Willingness to pay for hepatitis B vaccination in Selangor, Malaysia: A cross-sectional household survey.PloS one · 2019Article
- Persistence of Vaccine-Induced Immunity in Preschool Children: Effect of Gestational Age.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- Review
- Post-vaccination Immunity Against Hepatitis B Virus and Predictors for Non-responders Among Medical Staff.Jundishapur journal of microbiology · 2015Article
- Absence of occult hepatitis B virus infection in sera of diabetic children and adolescents following hepatitis B vaccination.Human vaccines & immunotherapeutics · 2014Article
- The persistence of anti-HBs antibody and anamnestic response 20 years after primary vaccination with recombinant hepatitis B vaccine at infancy.Human vaccines & immunotherapeutics · 2014Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThis study aimed to evaluate the level of hepatitis B immunity among undergraduate students 23 years after commencement of the nationwide hepatitis B childhood immunization program in Malaysia.
methodsA total of 402 serum samples obtained from volunteer undergraduate students were screened for the presence of hepatitis B surface antibodies using qualitative ELISA.
resultsResults showed that 62.7% of volunteers had protective anti-hepatitis B surface antigens (≥10 IU/L), of whom 67.9% received three doses of the vaccine. The estimated post-vaccination immunity was found to be at least 20 years, indicating persistent immunity against hepatitis B and a significant association (P < 0.05) with duration of vaccination. Anamnestic response 1 month post-hepatitis B booster was 94.0% and highly significant (P < 0.01). Isolated antihepatitis B core antigen (anti-HBc) prevalence was found to be 5.0%, all having had a positive anamnestic response.
conclusionImmunity after primary vaccination with hepatitis B recombinant vaccine persists for at least 20 years post-vaccination, with significant association with the number of vaccinations. Furthermore, the presence of anamnestic response to booster vaccine indicates long-lasting immunity despite decreasing antibody levels; therefore, the need for hepatitis B vaccine boosters may not be of significant benefit after complete infant vaccination.
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