ArticleAnnals of Indian Academy of Neurology2013
Usefulness of medial temporal lobe atrophy visual rating scale in detecting Alzheimer's disease: Preliminary study.
Article in Annals of Indian Academy of Neurology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed, 8 citations in OpenAlex.
- Loss of corneal nerves and brain volume in mild cognitive impairment and dementia.Alzheimer's & dementia (New York, N. Y.) · 2022Article
- Evaluation of MR Visual Rating Scales in Major Forms of Dementia.Journal of neurosciences in rural practice · 2021Article
- Corneal Nerve and Brain Imaging in Mild Cognitive Impairment and Dementia.Journal of Alzheimer's disease : JAD · 2020Article
- Hippocampal atrophy has limited usefulness as a diagnostic biomarker on the early onset Alzheimer's disease patients: A comparison between visual and quantitative assessment.NeuroImage. Clinical · 2019Article
- Quantitative EEG and medial temporal lobe atrophy in Alzheimer's dementia: Preliminary study.Annals of Indian Academy of NeurologyArticle
- Correlation between hippocampal volumes and medial temporal lobe atrophy in patients with Alzheimer's disease.Annals of Indian Academy of NeurologyArticle
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4 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundThe Korean version of Mini-Mental Status Examination (K-MMSE) and the Korean version of Addenbrooke Cognitive Examination (K-ACE) have been validated as quick neuropsychological tests for screening dementia in various clinical settings. Medial temporal atrophy (MTA) is an early pathological characteristic of Alzheimer's disease (AD). We aimed to assess the diagnostic validity of the fusion of the neuropsychological test and visual rating scale (VRS) of MTA in AD. MATERIALS AND
methodsA total of fifty subjects (25 AD, 25 controls) were included. The neuropsychological tests used were the K-MMSE and the K-ACE. T1 axial imaging visual rating scale (VRS) was applied for assessing the grade of MTA. We calculated the fusion score with the difference of neuropsychological test and VRS of MTA. The receiver operating characteristics (ROC) curve was used to determine optimal cut-off score, sensitivity and specificity of the fusion scores in screening AD.
resultsNo significant differences in age, gender and education were found between AD and control group. The values of K-MMSE, K-ACE, CDR, VRS and cognitive function test minus VRS were significantly lower in the AD group than control group. The AUC (Area under the curve), sensitivity and specificity for K-MMSE minus VRS were 0.857, 84% and 80% and for K-ACE minus VRS were 0.884, 80% and 88%, respectively. Those for K-MMSE only were 0.842, 76% and 72% and for K-ACE only were 0.868, 80% and 88%, respectively.
conclusionsThe fusion of the neuropsychological test and VRS suggested clinical usefulness in their easy and superiority over neuropsychological test only. However, this study failed to find any difference. This may be because of small numbers in the study or because there is no true difference.
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