ArticlePediatrics2013
Central line maintenance bundles and CLABSIs in ambulatory oncology patients.
Article in Pediatrics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.
- The effects of care bundles on patient outcomes: a systematic review and meta-analysis.Implementation science : IS · 2017Pooled it
- Alcohol-impregnated caps and ambulatory central-line-associated bloodstream infections (CLABSIs): A randomized clinical trial.Infection control and hospital epidemiology · 2021Trial
- Outcome of Pediatric, Adolescent, and Young Adult Oncology Patients With Non-neutropenic Fever: A Scoping Review of the Literature.Current pediatric reviews · 2026Article
- Implementation frameworks, strategies and outcomes in optimizing central venous access device practice in paediatrics: A scoping review.Journal of advanced nursing · 2025Article
- Central line-associated bloodstream infection rates in pediatric short bowel syndrome in the United States: A retrospective cohort study from 2016 to 2023.JPEN. Journal of parenteral and enteral nutrition · 2025Article
- Central-line-associated bloodstream infections and central-line-associated non-CLABSI complications among pediatric oncology patients.Infection control and hospital epidemiology · 2023Article
- Development of a Clinical Prediction Model for Central Line-Associated Bloodstream Infection in Children Presenting to the Emergency Department.Pediatric emergency care · 2020Article
- Readmission Diagnoses After Pediatric Severe Sepsis Hospitalization.Critical care medicine · 2019Observational
- Adverse Events in Hospitalized Pediatric Patients.Pediatrics · 2018Article
- Medically Attended Catheter Complications Are Common in Patients With Outpatient Central Venous Catheters.Infection control and hospital epidemiology · 2018Observational
- Bacterial bloodstream infections in the allogeneic hematopoietic cell transplant patient: new considerations for a persistent nemesis.Bone marrow transplantation · 2017Review
- Do Clinicians Understand Quality Metric Data? An Evaluation in a Twitter-Derived Sample.Journal of hospital medicine · 2017Article
- Surveillance of bloodstream infections in pediatric cancer centers - what have we learned and how do we move on?GMS hygiene and infection control · 2016Review
- Bringing central line-associated bloodstream infection prevention home: catheter maintenance practices and beliefs of pediatric oncology patients and families.Joint Commission journal on quality and patient safety · 2015Article
- Impact of a modified Broviac maintenance care bundle on bloodstream infections in paediatric cancer patients.GMS hygiene and infection control · 2015Article
- Increasing Recognition and Diagnosis of Adolescent Depression: Project RedDE: A Cluster Randomized Trial.Pediatric quality & safetyArticle
- Project RedDE: Cluster Randomized Trial to Reduce Missed or Delayed Abnormal Laboratory Value Actions.Pediatric quality & safetyArticle
- Developing the Key Driver Diagram by Analyzing Home Central Line Caregiver Proficiency Factors.Pediatric quality & safetyArticle
- Cluster Randomized Trial Reducing Missed Elevated Blood Pressure in Pediatric Primary Care: Project RedDE.Pediatric quality & safetyArticle
- Quality Improvement Interventions across a Network of Pediatric Hematology-Oncology Clinics.Pediatric quality & safetyArticle
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 2 countries.
Funding
Abstract
objectivePediatric oncology patients are frequently managed with central lines as outpatients, and these lines confer significant morbidity in this immune-compromised population. We aimed to investigate whether a multidisciplinary, central line maintenance care bundle reduces central line-associated bloodstream infections (CLABSIs) and bacteremias in ambulatory pediatric oncology patients.
methodsWe conducted an interrupted time-series study of a maintenance bundle concerning all areas of central line care. Each of 3 target groups (clinic staff, homecare agency nurses, and patient families) (1) received training on the bundle and its importance, (2) had their practice audited, and (3) were shown CLABSI rates through graphs, in-service training, and bulletin boards. CLABSI and bacteremia person-time incidence rates were collected for 23 months before and 24 months after beginning the intervention and were compared by using a Poisson regression model.
resultsThe mean CLABSI rate decreased by 48% from 0.63 CLABSIs per 1000 central line days at baseline to 0.32 CLABSIs per 1000 central line days during the intervention period (P = .005). The mean bacteremia rate decreased by 54% from 1.27 bacteremias per 1000 central line days at baseline to 0.59 bacteremias per 1000 central line days during the intervention period (P < .001).
conclusionsImplementation of a multidisciplinary, central line maintenance care bundle significantly reduced CLABSI and bacteremia person-time incidence rates in ambulatory pediatric oncology patients with central lines. Further research is needed to determine if maintenance care bundles reduce ambulatory CLABSIs and bacteremia in other adult and pediatric populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.