ArticlePediatrics2013
Apnea in children hospitalized with bronchiolitis.
Article in Pediatrics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 83 citations in OpenAlex.
- Caffeine and other methylxanthines' impact on bronchiolitis-related apnea in under 12-months-old children-a systematic review with meta-analyses.European journal of pediatrics · 2026Pooled it
- Caffeine for the Treatment of Apnea in Bronchiolitis: A Randomized Trial.The Journal of pediatrics · 2016Trial
- Biomarkers and Risk Factors Associated with Apnea in Hospitalized Infants with Acute Respiratory Infection.Viruses · 2026Article
- Age-related pharyngeal microbiome and host transcriptomic signatures underlying fever responses in RSV bronchiolitis.Virologica Sinica · 2026Article
- Significant Cardiac Rhythm Disturbances in Infant Bronchiolitis: A Holter-Based Prospective Analysis.Journal of pediatrics. Clinical practice · 2026Article
- Article
- Successful Use of Caffeine Citrate for Neonate With Bronchiolitis-Related Apnea: Case Report and Clinical Insights.Clinical case reports · 2025Article
- Saline nebulizers in treatment of bronchiolitis.Journal of family medicine and primary care · 2024Article
- Myositis "Diaphragm Cramp" as a Potential Cause of Respiratory Arrests in Infants. Comment on Salfi, N.C.M. et al. Fatal Deterioration of a Respiratory Syncytial Virus Infection in an Infant with Abnormal Muscularization of Intra-Acinar Pulmonary Arteries: Autopsy and Histological Findings.Diagnostics (Basel, Switzerland) · 2024Article
- Respiratory Syncytial Virus Infection and Apnea Risk As Criteria for Hospitalization in Full Term Healthy Infants.Cureus · 2024Article
- Establishment and validation of a prediction model for apnea on bronchiolitis.Frontiers in pediatrics · 2024Article
- Factors associated with mild bronchiolitis in young infants.Journal of the American College of Emergency Physicians open · 2023Article
- Cardiorespiratory alterations in a newborn ovine model of systemic viral inflammation.Pediatric research · 2022Article
- Prostaglandin E2 Exerts Biphasic Dose Response on the PreBötzinger Complex Respiratory-Related Rhythm.Frontiers in neural circuits · 2022Article
- Development and external validation of a simple nomogram for predicting apnea in children hospitalized with bronchiolitis.Frontiers in pediatrics · 2022Article
- Clinico-virological Profile, Intensive Care Needs, and Outcome of Infants with Acute Viral Bronchiolitis: A Prospective Observational Study.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2021Article
- Patient, Provider, and Health Care System Characteristics Associated With Overuse in Bronchiolitis.Pediatrics · 2021Article
- Article
- COVID-19 Associated With Life-Threatening Apnea in an Infant Born Preterm: A Case Report.Frontiers in pediatrics · 2020Article
- Association of Serum Albumin With Apnea in Infants With Bronchiolitis: A Secondary Analysis of Data From the MARC-35 Study.JAMA network open · 2019Article
Corrections and comments
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Authors and funding
10 authors at 9 institutions in 1 country.
Funding
Abstract
objectiveTo identify risk factors for inpatient apnea among children hospitalized with bronchiolitis.
methodsWe enrolled 2207 children, aged <2 years, hospitalized with bronchiolitis at 16 sites during the winters of 2007 to 2010. Nasopharyngeal aspirates (NPAs) were obtained on all subjects, and real-time polymerase chain reaction was used to test NPA samples for 16 viruses. Inpatient apnea was ascertained by daily chart review, with outcome data in 2156 children (98%). Age was corrected for birth <37 weeks. Multivariable logistic regression was performed to identify independent risk factors for inpatient apnea.
resultsInpatient apnea was identified in 108 children (5%, 95% confidence interval [CI] 4%-6%). Statistically significant, independent predictors of inpatient apnea included: corrected ages of <2 weeks (odds ratio [OR] 9.67) and 2 to 8 weeks (OR 4.72), compared with age ≥ 6 months; birth weight <2.3 kg (5 pounds; OR 2.15), compared with ≥ 3.2 kg (7 pounds); caretaker report of previous apnea during this bronchiolitis episode (OR 3.63); preadmission respiratory rates of <30 (OR 4.05), 30 to 39 (OR 2.35) and >70 (OR 2.26), compared with 40 to 49; and having a preadmission room air oxygen saturation <90% (OR 1.60). Apnea risk was similar across the major viral pathogens.
conclusionsIn this prospective, multicenter study of children hospitalized with bronchiolitis, inpatient apnea was associated with younger corrected age, lower birth weight, history of apnea, and preadmission clinical factors including low or high respiratory rates and low room air oxygen saturation. Several bronchiolitis pathogens were associated with apnea, with similar apnea risk across the major viral pathogens.
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Registered trials
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